2013
A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryFunctional connectivityNegative connectivityAmygdala reactivityRecent human imagingParticipants 10 yearsTask-based functional magnetic resonance imagingNegative functional connectivityFunctional magnetic resonance imagingMagnetic resonance imagingAmygdala-prefrontal connectivityAmygdala-cortical connectivityAnxiety-related disordersFrontoamygdala circuitryAnimal studiesReciprocal connectionsResonance imagingTracing studyPositive connectivityAdolescent periodEarly childhoodNeurobiological basisEmotional behaviorPresent studyDevelopmental changes
2011
Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study
Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T, Woods SW, Addington J, Cadenhead KS, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Cannon TD, Consortium O. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study. Schizophrenia Research 2011, 134: 1-9. PMID: 22056201, PMCID: PMC3245800, DOI: 10.1016/j.schres.2011.10.005.Peer-Reviewed Original ResearchConceptsClinical high riskFunctional connectivityPrefrontal cortexCHR adolescentsHigh riskAmygdala-prefrontal functional connectivityAmygdala-prefrontal circuitryCross-sectional analysisPsychophysiological interaction analysisVLPFC activationIllness onsetAge-related trajectoriesRisk syndromeVentrolateral prefrontal cortexInteraction of ageOvert psychosisAge-related variationsPsychosisAmygdala reactivityBrain connectivityFunctional activationAmygdalaCortexLater deficitsFMRI task