2023
Connectome-based prediction of craving in gambling disorder and cocaine use disorder
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Connectome-based prediction of craving in gambling disorder and cocaine use disorder. Dialogues In Clinical Neuroscience 2023, 25: 33-42. PMID: 37190759, PMCID: PMC10190201, DOI: 10.1080/19585969.2023.2208586.Peer-Reviewed Original ResearchConceptsCocaine use disorderGambling disorderBehavioral addictionsCue-reactivity taskComponents of memoryGeneral neural mechanismCommon neural networkFunctional magnetic resonanceMedial frontal regionsDefault mode networkFeatures of addictionAutobiographical memoryValence ratingsMeta-analytic dataPrefrontal regionsNeural mechanismsPrefrontal cortexFronto-parietalFrontal regionsMotor imageryMotor/Diverse sampleLimbic networkNeural connectivityCraving
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode network
2021
A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regions
2020
Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study
Netto JMB, Scheinost D, Onofrey JA, Franco I. Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study. Journal Of Pediatric Urology 2020, 16: 536-542. PMID: 32873504, DOI: 10.1016/j.jpurol.2020.08.002.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexAnterior cingulate cortexOveractive bladderFunctional connectivityPrefrontal cortexUrinary tract symptomsSacral nerve stimulatorCommon treatment modalityRight scapular regionACC functional connectivityResting-state conditionsMechanism of actionTract symptomsMotor thresholdCentral effectsACC connectivityNerve stimulatorSacral levelTreatment modalitiesFunctional connectivity dataMechanism of effectivenessAdult volunteersFrontal lobeSubcortical regionsCingulate cortex
2019
Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles
Taylor-Giorlando M, Scheinost D, Ment L, Rothman D, Horvath TL. Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles. Cerebral Cortex 2019, 29: 5061-5071. PMID: 30877804, PMCID: PMC6918927, DOI: 10.1093/cercor/bhz046.Peer-Reviewed Original ResearchConceptsMode of deliverySurgical deliveryLayer 3 pyramidal neuronsAlters mitochondrial dynamicsValues of miceMurine findingsCerebral cortexPyramidal neuronsAdult behaviorHuman neonatesMaze testPrepulse inhibitionSpine synapsesPsychiatric illnessAdult miceNeuronal circuitryAnimal modelsClinical relevanceHuman clinical relevanceUCP-2Prefrontal cortexMitochondrial adaptationsImpaired performanceMitochondrial mechanismsBehavioral phenotypes
2018
Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network
Scheinost D, Tokoglu F, Hampson M, Hoffman R, Constable RT. Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network. Schizophrenia Bulletin 2018, 45: 415-424. PMID: 29660081, PMCID: PMC6403094, DOI: 10.1093/schbul/sby039.Peer-Reviewed Original ResearchConceptsAuditory Hallucination Rating ScaleIntrinsic connectivity distributionAuditory verbal hallucinationsHealthy controlsFunctional connectivityLateralized connectivitySevere global health problemSeed connectivity analysesBest treatment strategyGlobal health problemWhole-brain connectivityMedial prefrontal cortexPosterior cingulate cortexDefault mode networkSuch patientsPatient groupLeft putamenTreatment strategiesPatientsActionable targetsSchizoaffective disorderCingulate cortexHealth problemsVoxel-based measurePrefrontal cortexCerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence
Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.Peer-Reviewed Original ResearchPosttraumatic stress disorderIntrinsic connectivity distributionMedial prefrontal cortexTensor-based morphometryPTSD groupFunctional connectivityPrefrontal cortexPathophysiology of PTSDGray matter volumeWhole-brain connectivityKey brain regionsMiddle temporal gyrusDorsolateral prefrontal cortexDefault mode networkCentral executive networkFunctional connectivity analysisPFC alterationsCortical alterationsHealthy comparison participantsAltered volumeFunctional alterationsMatter volumeUnmedicated individualsCerebellar involvementBrain regions
2014
Resting state functional connectivity predicts neurofeedback response
Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M. Resting state functional connectivity predicts neurofeedback response. Frontiers In Behavioral Neuroscience 2014, 8: 338. PMID: 25309375, PMCID: PMC4173810, DOI: 10.3389/fnbeh.2014.00338.Peer-Reviewed Original ResearchObsessive-compulsive disorderOrbitofrontal cortexFunctional connectivityNeurofeedback trainingState functional connectivityWhole-brain connectivityBrain functional connectivityResting-state fMRITarget brain regionsBrodmann area 10Clinical symptomatologyContamination anxietyProminent symptomAnterior prefrontal cortexBrain regionsNeuropsychiatric disordersRs-fMRIBehavioral improvementPrefrontal cortexSame protocolPilot dataBA 10Neurofeedback protocolReliable predictorCortex
2013
Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks