2023
Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort
Westwater M, Mallard T, Warrier V, Bethlehem R, Scheinost D, Grillon C, Fletcher P, Seidlitz J, Ernst M. Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort. Nature Mental Health 2023, 1: 573-585. DOI: 10.1038/s44220-023-00101-4.Peer-Reviewed Original ResearchNeurobiological factorsPsychopathology symptomsFactor scoresCanonical brain networksThree-factor structureStructural equation modelingCritical developmental periodGray matter volumeCortical thicknessGreater genetic riskDisorder symptomatologyABCD studyEarly adolescenceDefault modeBrain networksAnxiety disordersGenetic riskIntervention effortsABCD cohortEquation modelingSubcortical gray matter volumesPsychopathology factorDevelopmental periodFear factorBrain structures
2019
Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling
Lichenstein SD, Scheinost D, Potenza MN, Carroll KM, Yip SW. Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling. Molecular Psychiatry 2019, 26: 4383-4393. PMID: 31719641, PMCID: PMC7214212, DOI: 10.1038/s41380-019-0586-y.Peer-Reviewed Original ResearchConceptsBrain statesDissociable neural substratesMultiple brain statesSubstance use outcomesHealthy comparison subjectsWhole-brain approachFMRI scanningFrontoparietal networkNeural substratesSubstance use treatmentNeural mechanismsDifferent brain statesFurther clinical relevanceDefault modeFMRI dataSubject replicationTreatment approachesReduced connectivityUse outcomesComparison subjectsNetwork strengthUse disordersSensory networksTreatment respondersSensory connectivity
2017
Multi-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks
Qiu M, Scheinost D, Ramani R, Constable RT. Multi-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks. NeuroImage 2017, 148: 130-140. PMID: 28069540, PMCID: PMC5410383, DOI: 10.1016/j.neuroimage.2016.12.080.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntrinsic connectivity distributionLarge-scale brain networksFunctional connectivityReduced consciousnessBlood flowBrain networksSedation conditionsWhole-brain connectivityAltered connectivityMotor networkCBF dataRs-fMRIPharmacological alterationsConnectivity differencesPropofolMultiple large-scale brain networksUnique neural correlatesBlow flowFrontoparietal networkAnesthesiaKey markersDefault modeNeural correlatesSame subjects