2019
Genomic sites hypersensitive to ultraviolet radiation
Premi S, Han L, Mehta S, Knight J, Zhao D, Palmatier MA, Kornacker K, Brash DE. Genomic sites hypersensitive to ultraviolet radiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 24196-24205. PMID: 31723047, PMCID: PMC6883822, DOI: 10.1073/pnas.1907860116.Peer-Reviewed Original ResearchMeSH Keywords5' Untranslated RegionsCells, CulturedDNA DamageFibroblastsGene Expression RegulationGenome, HumanHigh-Throughput Nucleotide SequencingHumansMelanocytesMelanomaMutationPromoter Regions, GeneticProtein BiosynthesisPyrimidine DimersPyrimidine NucleotidesSkin NeoplasmsTOR Serine-Threonine KinasesUltraviolet RaysConceptsCyclobutane pyrimidine dimersETS family transcription factorsIndividual gene promotersFamily transcription factorsRNA-binding proteinPrimary human melanocytesSingle-base resolutionEpigenetic marksGenomic averageTranslation regulationGenomic sitesMotif locationsTranscription factorsCell physiologyGene promoterCancer driversGenomeHuman melanocytesCell typesTumor evolutionCell pathwaysRare mutationsUV targetPyrimidine dimersApurinic sites
2014
Common Contaminants in Next-Generation Sequencing That Hinder Discovery of Low-Abundance Microbes
Laurence M, Hatzis C, Brash DE. Common Contaminants in Next-Generation Sequencing That Hinder Discovery of Low-Abundance Microbes. PLOS ONE 2014, 9: e97876. PMID: 24837716, PMCID: PMC4023998, DOI: 10.1371/journal.pone.0097876.Peer-Reviewed Original ResearchConceptsLow-abundance microbesNCBI genome databaseHigh-throughput sequencingShotgun DNA librariesUnbiased high-throughput sequencingNovel microbesGenome databaseDNA libraryNext-generation sequencingComplete genomeGenome ProjectKnown sequencesSequencing runMicrobesSequencing applicationsGenomeCommon contaminantsSequencingLaboratory contaminantsClinical specimensGenusNCBISpeciesDiversityReads
1991
Ultraviolet Mutagenesis of a Shuttle Vector Plasmid in Repair Proficient and Deficient Human Cells
Seidman M, Brash D, Settharam S, Kraemer K, Bredberg A. Ultraviolet Mutagenesis of a Shuttle Vector Plasmid in Repair Proficient and Deficient Human Cells. 1991, 183-192. DOI: 10.1007/978-1-4615-3732-8_23.ChaptersDNA sequence dataRecombinant DNA revolutionStudy of mutagenesisDeficient human cellsMechanisms of mutagenesisMammalian genomesNature of mutationsMammalian cellsShuttle vector plasmidSequence dataProkaryotic systemDNA revolutionShuttle vectorHuman cellsMutagenesisVector plasmidRepair proficientMutagenic agentsUltraviolet mutagenesisGenomeCellsFundamental questionsEnormous bodyGeneticsPlasmid