2020
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
McGee EE, Kim CH, Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research 2020, 22: 78. PMID: 32698885, PMCID: PMC7374956, DOI: 10.1186/s13058-020-01316-4.Peer-Reviewed Original ResearchConceptsBreast cancer riskImmuno-inflammatory markersErythrocyte membrane fatty acidsCase-control studyTumor tissue expressionFatty acid synthaseCancer riskTrans fatty acidsExpression subtypesOdds ratioSpecific fatty acidsLogistic regressionHealth Study IITumor tissue blocksMembrane fatty acidsFatty acidsUnconditional logistic regressionConfidence intervalsTissue expressionT cell functionPolytomous logistic regressionAcid synthaseTumor CD4Potential confoundersTumor expression
2018
Phthalate Metabolites and Postmenopausal Breast Cancer Risk
Reeves K, Diaz S, Hankinson, Bigelow C, Zoeller, Manson J, Spiegelman D, Tinker L. Phthalate Metabolites and Postmenopausal Breast Cancer Risk. Cancer Epidemiology Biomarkers & Prevention 2018, 27: 355-355. DOI: 10.1158/1055-9965.epi-18-0052.Peer-Reviewed Original ResearchBreast cancer riskPhthalate metabolitesCancer riskWomen’s Health Initiative prospective cohortMultivariable conditional logistic regression analysisConditional logistic regression analysisHuman breast cancer riskIndividual phthalate metabolitesBody mass indexMono-2-ethylhexyl phthalateAnimal model evidenceCase-control studyHuman breast milkLogistic regression analysisRace/ethnicityProspective cohortSmoking statusEnrollment dateMass indexBreast milkProspective dataRisk ratioStudy groupMonoethyl phthalateResults Overall
2005
Dietary Patterns and the Risk of Breast Cancer
Adebamowo CA, Hu FB, Cho E, Spiegelman D, Holmes MD, Willett WC. Dietary Patterns and the Risk of Breast Cancer. Annals Of Epidemiology 2005, 15: 789-795. PMID: 16257363, DOI: 10.1016/j.annepidem.2005.01.008.Peer-Reviewed Original ResearchConceptsPrudent dietary patternDietary patternsBreast cancerNurses' Health Study IIMajor dietary patternsHealth Study IIWestern dietary patternFood frequency questionnaireInvasive breast cancerPre-menopausal womenBreast cancer riskSecular trend studiesCumulative average scoreMultivariate RRsPremenopausal womenFrequency questionnaireLowest quintileInverse associationWestern dietCancer riskOverall associationCancerFurther evaluationStudy IIRiskDietary flavonols and flavonol‐rich foods intake and the risk of breast cancer
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer. International Journal Of Cancer 2005, 114: 628-633. PMID: 15609322, DOI: 10.1002/ijc.20741.Peer-Reviewed Original ResearchConceptsMultivariate relative riskBreast cancer riskCumulative average intakeFlavonol-rich foodsIntake of beansRelative riskBreast cancerCancer riskFlavonol intakeLowest quintileInverse associationDietary flavonolsAverage intakeNurses' Health Study IIIntake of flavonolsHealth Study IIFood frequency questionnaireInvasive breast cancerSignificant inverse associationFrequency questionnaireEpidemiological studiesAnimal studiesDietary dataOverall associationFurther evaluationPlasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Campos H, Spiegelman D, Zhang S, Colditz GA, Willett WC, Hunter DJ. Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer. American Journal Of Epidemiology 2005, 161: 153-160. PMID: 15632265, DOI: 10.1093/aje/kwi030.Peer-Reviewed Original ResearchConceptsLutein/zeaxanthinBreast cancerHealth StudyPlasma carotenoidsNurses' Health StudyBreast cancer riskCase-control studyBreast cancer etiologyNodal metastasisHighest quintileInvasive cancerLowest quintileBlood drawInverse associationCancer riskAlpha-tocopherolCancerCancer etiologyGamma-tocopherolWomenRetinolQuintileRiskRole of carotenoidsAssociation
2004
Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stress
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoidsThe HRAS1 variable number of tandem repeats and risk of breast cancer.
Tamimi RM, Hankinson SE, Ding S, Gagalang V, Larson GP, Spiegelman D, Colditz GA, Krontiris TG, Hunter DJ. The HRAS1 variable number of tandem repeats and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1528-30. PMID: 14693748.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesBreast NeoplasmsCase-Control StudiesDNA, NeoplasmFemaleGenes, rasGenetic Predisposition to DiseaseGenotypeHumansLogistic ModelsMiddle AgedMinisatellite RepeatsPolymerase Chain ReactionPolymorphism, GeneticProbabilityPrognosisReference ValuesRisk AssessmentSensitivity and SpecificityTandem Repeat SequencesConceptsHealth Study cohortBreast cancer casesBreast cancerCancer casesNurses' Health Study cohortIncident breast cancer casesHRAS1 VNTRHRAS1 variable numberBreast cancer riskCase-control studyGene-dose effectRare HRAS1 allelesMenopausal statusStudy cohortCancer riskOverall associationCancerHRAS1 allelesRiskRare allelesAssociationCommon allelesAllelesVariable numberCohortPremenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Colditz GA, Willett WC. Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1153-8. PMID: 14652274.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer riskHealth Study IIGlycemic loadCarbohydrate intakeCancer riskBreast cancerGlycemic indexDietary carbohydrateRelative riskFiber intakeNurses' Health Study IIMultivariate relative riskCorresponding relative risksFood frequency questionnaireInvasive breast cancerDietary carbohydrate intakeEarly adult lifeYoung adult womenPremenopausal womenFrequency questionnaireLean womenOverall cohortOverweight womenMass indexPremenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Zhang SM, Colditz GA, Willett WC. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 713-20. PMID: 12917201.Peer-Reviewed Original ResearchConceptsHealth Study IIBreast cancer riskBreast cancerVitamin ACancer riskNurses' Health Study IIMultivariate relative riskFood frequency questionnaireInvasive breast cancerPrevious epidemiological studiesEarly adult lifePostmenopausal womenPremenopausal womenIncident casesHighest quintileLowest quintileRelative riskHigh intakeEpidemiological studiesNutrient intakeTotal vitaminCancerStudy IIIntakeVitamin CPremenopausal Fat Intake and Risk of Breast Cancer
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. Premenopausal Fat Intake and Risk of Breast Cancer. Journal Of The National Cancer Institute 2003, 95: 1079-1085. PMID: 12865454, DOI: 10.1093/jnci/95.14.1079.Peer-Reviewed Original ResearchConceptsBreast cancer riskDietary fat intakeHigh-fat dairy foodsHealth Study IIFat intakeBreast cancerCancer riskRelative riskPremenopausal womenIncident invasive breast cancerNurses' Health Study IIElevated breast cancer riskRed meatMultivariable relative risksAnimal fat intakeFood frequency questionnaireInvasive breast cancerConfidence intervalsCase-control studyDairy foodsPremenopausal yearsPostmenopausal womenProspective studyHighest quintileLowest quintile
2002
The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.
Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Research 2002, 62: 1045-9. PMID: 11861380.Peer-Reviewed Original ResearchConceptsFirst-degree family historyBreast cancer riskHealth Study cohortAndrogen receptorBreast cancerCancer riskFamily historyAR genotypeCaucasian womenHormone levelsHealth StudyNurses' Health Study cohortBreast cancer risk factorsEndogenous steroid hormone levelsNurses' Health StudyCancer risk factorsPostmenopausal Caucasian womenCase-control studyAndrogen receptor genotypeAndrogen receptor CAGAndrogen receptor allelesSteroid hormone levelsShort alleleLong alleleSignificant positive associationMeat and dairy food consumption and breast cancer: a pooled analysis of cohort studies
Missmer SA, Smith-Warner SA, Spiegelman D, Yaun SS, Adami HO, Beeson WL, van den Brandt PA, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Kushi LH, Miller AB, Potter JD, Rohan TE, Speizer FE, Toniolo P, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hunter DJ. Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. International Journal Of Epidemiology 2002, 31: 78-85. PMID: 11914299, DOI: 10.1093/ije/31.1.78.Peer-Reviewed Original ResearchConceptsBreast cancer riskDairy food consumptionBreast cancerCancer riskCohort studyNon-dietary risk factorsSignificant associationFood consumptionIncident breast cancer casesEgg consumptionProspective cohort studyInvasive breast cancerDietary assessment instrumentsIntake of meatBreast cancer casesPooled analysisRisk factorsCancer casesPooled databaseNutrient intakeUsual foodCancerRed meatTotal meatWomen
2001
Types of dietary fat and breast cancer: A pooled analysis of cohort studies
Smith‐Warner S, Spiegelman D, Adami H, Beeson W, van den Brandt P, Folsom A, Fraser G, Freudenheim J, Goldbohm R, Graham S, Kushi L, Miller A, Rohan T, Speizer F, Toniolo P, Willett W, Wolk A, Zeleniuch‐Jacquotte A, Hunter D. Types of dietary fat and breast cancer: A pooled analysis of cohort studies. International Journal Of Cancer 2001, 92: 767-774. PMID: 11340585, DOI: 10.1002/1097-0215(20010601)92:5<767::aid-ijc1247>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsType of fatBreast cancer riskRelative riskCancer riskIncident invasive breast cancer casesStudy-specific relative risksInvasive breast cancer casesCarbohydrate consumptionVegetable fat intakePooled relative riskBreast cancer casesEquivalent energy intakeRandom-effects modelWeak positive associationCohort studyMenopausal statusFat intakeProspective studyPooled analysisDietary fatBreast cancerCancer casesPooled databaseEnergy intakeIntakeAssociation of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 711-4. PMID: 11401924.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskHormone levelsBreast cancerUGT1A1 genotypeCancer riskNurses' Health Study cohortPremenopausal breast cancer riskUDP-glucuronosyltransferasesBody mass indexCase-control studyPlasma hormone levelsUGT1A1 promoter polymorphismCommon insertion/deletion polymorphismInsertion/deletion polymorphismPostmenopausal womenHormone replacementMass indexStudy cohortEstradiol levelsEstradiol metabolismBlood drawCaucasian womenRelative riskAfrican American populationIntake of Fruits and Vegetables and Risk of Breast Cancer: A Pooled Analysis of Cohort Studies
Smith-Warner SA, Spiegelman D, Yaun SS, Adami HO, Beeson WL, van den Brandt PA, Folsom AR, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Miller AB, Potter JD, Rohan TE, Speizer FE, Toniolo P, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hunter DJ. Intake of Fruits and Vegetables and Risk of Breast Cancer: A Pooled Analysis of Cohort Studies. JAMA 2001, 285: 769-776. PMID: 11176915, DOI: 10.1001/jama.285.6.769.Peer-Reviewed Original ResearchConceptsBreast cancer casesBreast cancerRelative riskCancer casesVegetable consumptionSpecific fruitsIncident invasive breast cancer casesIncident breast cancer casesStudy-specific relative risksInvasive breast cancer casesTotal fruitIntake of fruitsUsual dietary intakeBreast cancer riskCase-control studyDiet assessment methodsRandom-effects modelCohort studyTotal vegetablesExposure definitionGroup intakesProspective studyGreen leafy vegetablesPooled analysisDietary intake
2000
Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women.
Holmes M, Spiegelman D, Willett W, Manson J, Hunter D, Barbieri R, Colditz G, Hankinson S. Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. Journal Of Clinical Oncology 2000, 18: 3668-76. PMID: 11054440, DOI: 10.1200/jco.2000.18.21.3668.Peer-Reviewed Original ResearchConceptsDietary fat intakeFat intakePostmenopausal womenInverse associationHormone levelsSex steroid hormone levelsHealthy postmenopausal womenTotal fat intakeFood frequency questionnaireEndogenous estrogen levelsBreast cancer riskOmega-3 fatsSex steroid hormonesCross-sectional associationsSteroid hormone levelsPercentage of energyEstradiol levelsEstrogen levelsPlasma sex steroidsPlasma levelsSex steroidsCancer riskProtein intakeEnergy intakeSteroid hormonesA prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.
Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 1099-105. PMID: 11045794.Peer-Reviewed Original ResearchConceptsBreast cancer riskAlcohol dehydrogenase type 3Hormone levelsCancer riskSteroid hormone levelsAlcohol intakeAlcohol consumptionADH3 genotypeHealth StudyADH3 polymorphismIncident breast cancer casesSex hormone-binding globulinOverall breast cancer riskPlasma steroid hormone levelsNurses' Health StudyHormone-binding globulinPartial Pearson correlation coefficientsCase-control studyConditional logistic regressionBreast cancer casesPostmenopausal womenProspective studyDehydroepiandrosterone sulfateRelative riskBreast cancerPolymorphic repeat in AIB1 does not alter breast cancer risk
Haiman C, Hankinson S, Spiegelman D, Colditz G, Willett W, Speizer F, Brown M, Hunter D. Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Research 2000, 2: 378. PMID: 11056690, PMCID: PMC13920, DOI: 10.1186/bcr82.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortCancer riskPostmenopausal breast cancer riskNurses' Health Study cohortBreast cancer incidenceCase-control studySpecific tumor characteristicsAIB1 genotypeStudy cohortTumor characteristicsCancer incidenceCaucasian womenGeneral populationAIB1Repeat polymorphismRiskAssociationCohortIncidenceGenotypesWomenPooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk
van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ. Pooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk. American Journal Of Epidemiology 2000, 152: 514-527. PMID: 10997541, DOI: 10.1093/aje/152.6.514.Peer-Reviewed Original ResearchConceptsBody mass indexProspective cohort studyPostmenopausal womenRelative riskPremenopausal womenBreast cancerRisk factorsCohort studyIncident invasive breast cancer casesBreast cancer risk factorsInvasive breast cancer casesIndependent risk factorPooled relative riskPostmenopausal breast cancerCancer risk factorsBreast cancer variesBreast cancer riskBreast cancer casesMenopausal statusCancer variesMass indexAnthropometric indicesCancer casesCancer riskWeight control