2001
Helical membrane proteins: diversity of functions in the context of simple architecture
Ubarretxena-Belandia I, Engelman D. Helical membrane proteins: diversity of functions in the context of simple architecture. Current Opinion In Structural Biology 2001, 11: 370-376. PMID: 11406389, DOI: 10.1016/s0959-440x(00)00217-7.Peer-Reviewed Original ResearchConceptsHelical membrane proteinsGenome-wide scaleAlpha-helical conformationDiversity of functionsIdentification of motifsMembrane proteinsProtein regionsHelix interactionsPolar sidechainsStructural roleLipid bilayersProteinDiversityMotifUse of deviationsConformationSidechainsFunctionFurther investigationBilayersSequestrationIdentification
1997
Assessment of the aggregation state of integral membrane proteins in reconstituted phospholipid vesicles using small angle neutron scattering11Edited by M. F. Moody
Hunt J, McCrea P, Zaccaı̈ G, Engelman D. Assessment of the aggregation state of integral membrane proteins in reconstituted phospholipid vesicles using small angle neutron scattering11Edited by M. F. Moody. Journal Of Molecular Biology 1997, 273: 1004-1019. PMID: 9367787, DOI: 10.1006/jmbi.1997.1330.Peer-Reviewed Original ResearchConceptsMembrane protein complexesIntegral membrane proteinsProtein complexesMembrane proteinsIntegral membrane protein complexPhospholipid vesiclesSmall unilamellar phospholipid vesiclesUnilamellar phospholipid vesiclesMolecular massF. MoodySpatial arrangementNon-ionic detergentIndividual complexesVesiclesModel systemMonomeric bacteriorhodopsinProteinUnknown scopeComplexesAggregation stateRadius of gyrationBacteriorhodopsinDetergentsBilayers
1996
Mapping the lipid-exposed surfaces of membrane proteins
Arkin I, MacKenzie K, Fisher L, Aimoto S, Engelman D, Smith S. Mapping the lipid-exposed surfaces of membrane proteins. Nature Structural & Molecular Biology 1996, 3: 240-243. PMID: 8605625, DOI: 10.1038/nsb0396-240.Peer-Reviewed Original ResearchConceptsMembrane proteinsLong transmembrane helixLipid-exposed surfaceThree-dimensional foldHigh-resolution structuresRelative rotational orientationTransmembrane helicesTransmembrane segmentsThird cysteineCysteine residuesLipid environmentHelix interfacePentameric complexProteinLipid interfaceStable complexesHelixResiduesUndergoes exchangeSulphydryl groupsPhospholambanComplexesInternal faceCysteineRotational orientation
1992
Thermodynamic measurements of the contributions of helix-connecting loops and of retinal to the stability of bacteriorhodopsin.
Kahn T, Sturtevant J, Engelman D. Thermodynamic measurements of the contributions of helix-connecting loops and of retinal to the stability of bacteriorhodopsin. Biochemistry 1992, 31: 8829-39. PMID: 1390670, DOI: 10.1021/bi00152a020.Peer-Reviewed Original ResearchIntramembrane Helix-Helix Association in Oligomerization and Transmembrane Signaling
Bormann B, Engelman D. Intramembrane Helix-Helix Association in Oligomerization and Transmembrane Signaling. Annual Review Of Biophysics 1992, 21: 223-242. PMID: 1326354, DOI: 10.1146/annurev.bb.21.060192.001255.Peer-Reviewed Original ResearchConceptsProtein foldingTransmembrane regionReceptor proteinClose contact sitesSignal transductionQuaternary structureReceptor moleculesConformational changesHelical transmembrane regionsAllosteric conformational changeHelix-helix associationConformational change modelTertiary/quaternary structureTransmembrane helicesTransmembrane domainMechanism of insertionCytoplasmic domainTransmembrane signalingContact sitesPrimary structureSecondary structureProteinOligomerizationFoldingProteolytic fragments
1978
The planar distributions of surface proteins and intramembrane particles in Acholeplasma laidlawii are differentially affected by the physical state of membrane lipids
Wallace B, Engelman D. The planar distributions of surface proteins and intramembrane particles in Acholeplasma laidlawii are differentially affected by the physical state of membrane lipids. Biochimica Et Biophysica Acta 1978, 508: 431-449. PMID: 638151, DOI: 10.1016/0005-2736(78)90090-1.Peer-Reviewed Original Research
1976
The influence of lipid state on the planar distribution of membrane proteins in Acholeplasma laidlawii
Wallace B, Richards F, Engelman D. The influence of lipid state on the planar distribution of membrane proteins in Acholeplasma laidlawii. Journal Of Molecular Biology 1976, 107: 255-269. PMID: 1003469, DOI: 10.1016/s0022-2836(76)80004-6.Peer-Reviewed Original Research