2019
Rudhira/BCAS3 couples microtubules and intermediate filaments to promote cell migration for angiogenic remodeling
Joshi D, Inamdar M. Rudhira/BCAS3 couples microtubules and intermediate filaments to promote cell migration for angiogenic remodeling. Molecular Biology Of The Cell 2019, 30: 1437-1450. PMID: 30995157, PMCID: PMC6724693, DOI: 10.1091/mbc.e18-08-0484.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementFocal AdhesionsHEK293 CellsHeLa CellsHumansIntermediate FilamentsMiceMicrotubulesNeoplasm ProteinsNeovascularization, PhysiologicProtein DomainsVimentinConceptsCell migrationCytoskeleton organizationMT stabilityIntermediate filamentsEC migrationCytoskeletal protein essentialMT-IFVimentin intermediate filamentsFocal adhesionsEndothelial cell migrationMouse developmentProtein essentialRudhiraAssign functionCytoskeleton modulationDynamic remodelingBlood vessel formationAngiogenic sproutingSprouting angiogenesisAngiogenic remodelingMicrotubulesEssential roleVessel formationSequence 3Migration
2018
Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning
Shetty R, Joshi D, Jain M, Vasudevan M, Paul J, Bhat G, Banerjee P, Abe T, Kiyonari H, VijayRaghavan K, Inamdar M. Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Scientific Reports 2018, 8: 5632. PMID: 29618843, PMCID: PMC5884795, DOI: 10.1038/s41598-018-24014-w.Peer-Reviewed Original ResearchConceptsMouse developmentGenome-wide transcriptome analysisFirst knockout mouseDirectional cell migrationExtracellular matrix organizationExtra-embryonic tissuesSpheroid sprouting assaysEmbryonic day 9.5Endothelial cellsCKO embryosCardiovascular patterningNull embryosTranscriptome analysisRudhiraVascular patterningCardiovascular developmentCytoskeletal proteinsMolecular processesMatrix organizationCell adhesionCell migrationDay 9.5Peptidase activityYolk sacEssential role