2000
One Polypeptide with Two Aminoacyl-tRNA Synthetase Activities
Stathopoulos C, Li T, Longman R, Vothknecht U, Becker H, Ibba M, Söll D. One Polypeptide with Two Aminoacyl-tRNA Synthetase Activities. Science 2000, 287: 479-482. PMID: 10642548, DOI: 10.1126/science.287.5452.479.Peer-Reviewed Original ResearchConceptsProlyl-tRNA synthetaseProtein synthesisCysteinyl-tRNA synthetase activityAmino-terminal sequenceSynthetase activityAminoacyl-tRNA synthetase activityCertain archaeaEvolutionary originMethanococcus jannaschiiGenome sequenceSubstrate specificityGenetic analysisSuch organismsMessenger RNARNA synthetasesSynthetaseSequenceArchaeaJannaschiiSynthetasesRNAOrganismsPolypeptideProlylProtein
1979
Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli.
Morgan S, Larossa R, Cheung A, Low B, Söll D. Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli. Biological Research 1979, 12: 415-26. PMID: 45219.Peer-Reviewed Original ResearchConceptsGlutaminyl-tRNA synthetaseLeucyl-tRNA synthetaseGlnR mutantRegulation of biosynthesisClasses of mutantsTemperature-resistant revertantsOperator-promoter regionAminoacyl-transfer RNA synthetasesStructural geneLeu genesRegulatory mutantsThermolabile leucyl-tRNA synthetaseMutantsResistant revertantsFormation of glutamineGlutamine synthetaseE. coli strainsEscherichia coliRNA synthetasesGenesSynthetaseElevated levelsRevertantsColi strainsGlnT