2000
Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes
Navaratnam D, Oberholtzer J. Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes. 2000, 55-68. DOI: 10.1007/978-1-4615-4223-0_4.Peer-Reviewed Original ResearchChannel genesGene expressionAuditory receptor epitheliumAdditional gene productsK channel genesBK channel variantsLevel of transcriptionHair cellsPotassium channel genesRNA processingAlternative splicingSingle geneGene productsReceptor hair cellsReceptor epitheliumExpression patternsComplex patternsGenesMolecular determinantsChannel variantsLarge familyChick basilar papillaPhenotypic heterogeneityBasilar papillaChannel isoforms
1997
Differential Distribution of Ca2+-Activated K+ Channel Splice Variants among Hair Cells along the Tonotopic Axis of the Chick Cochlea
Navaratnam D, Bell T, Tu T, Cohen E, Oberholtzer J. Differential Distribution of Ca2+-Activated K+ Channel Splice Variants among Hair Cells along the Tonotopic Axis of the Chick Cochlea. Neuron 1997, 19: 1077-1085. PMID: 9390520, DOI: 10.1016/s0896-6273(00)80398-0.Peer-Reviewed Original Research
1996
Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway
Navaratnam D, Su H, Scott S, Oberholtzer J. Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway. Nature Medicine 1996, 2: 1136-1139. PMID: 8837614, DOI: 10.1038/nm1096-1136.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsCarbazolesChickensCochleaColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesDNA ReplicationEnzyme ActivationEnzyme InhibitorsGentamicinsHair Cells, AuditoryHearing Loss, SensorineuralIndolesIsoquinolinesOrgan Culture TechniquesPyrrolesRegenerationSignal TransductionSulfonamidesConceptsAuditory receptor epitheliumProtein kinase AHair cellsReplacement hair cellsReceptor epitheliumNew hair cellsProliferative responseRegenerative proliferationReceptor hair cellsKinase ASignaling pathwaysPKA inhibitorGentamicin damageCellular recoveryCyclic AMP levelsCell populationsFunctional recoveryBacterial insultPathwayProliferation markersProliferationAMP levelsCellsEpitheliumIntense sound
1995
Permeation Properties and Differential Expression across the Auditory Receptor Epithelium of an Inward Rectifier K+ Channel Cloned from the Chick Inner Ear *
Navaratnam D, Escobar L, Covarrubias M, Oberholtzer J. Permeation Properties and Differential Expression across the Auditory Receptor Epithelium of an Inward Rectifier K+ Channel Cloned from the Chick Inner Ear *. Journal Of Biological Chemistry 1995, 270: 19238-19245. PMID: 7642595, DOI: 10.1074/jbc.270.33.19238.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBariumBase SequenceBasilar MembraneChickensCloning, MolecularDNA, ComplementaryEpitheliumEvoked PotentialsGene Expression RegulationGlutamic AcidHair Cells, AuditoryMolecular Sequence DataPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingSequence Homology, Amino AcidXenopusConceptsAuditory receptor epitheliumDifferential expressionSingle-channel conductanceExcellent model systemSite-directed mutagenesisPutative pore regionIon channel genesInward rectifier potassium channelChick inner earCochlear sensory epitheliumReceptor epitheliumChick cochlear hair cellsChannel genesPrimary structureCochlear hair cellsNative channelsRectifier potassium channelSensory epitheliumExternal vestibulePore regionModel systemHair cellsPotassium channelsExpressionInward rectifier potassium current