2024
Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs
Wang T, Ling A, Billings S, Hosseini D, Vaisbuch Y, Kim G, Atkinson P, Sayyid Z, Aaron K, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore L, Maria P, Blevins N, Jackler R, Alyono J, Kveton J, Navaratnam D, Heller S, Lopez I, Grillet N, Jan T, Cheng A. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nature Communications 2024, 15: 4833. PMID: 38844821, PMCID: PMC11156867, DOI: 10.1038/s41467-024-48491-y.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptome atlasInner ear hair cell lossNon-sensory cell typesCell regeneration in vivoVestibular schwannoma patientsTranscriptomic atlasHair cellsHair cell lossIGF-1 signalingHuman inner earMouse hair cellsCell trajectory analysisSchwannoma patientsDynamic gene expressionVestibular hair cellsPermanent hearingHair cell precursorsIGF-1Cell lossCell precursorsInner earRegenerative capacityMurine utriclesCell typesGene expression
2000
Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes
Navaratnam D, Oberholtzer J. Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes. 2000, 55-68. DOI: 10.1007/978-1-4615-4223-0_4.Peer-Reviewed Original ResearchChannel genesGene expressionAuditory receptor epitheliumAdditional gene productsK channel genesBK channel variantsLevel of transcriptionHair cellsPotassium channel genesRNA processingAlternative splicingSingle geneGene productsReceptor hair cellsReceptor epitheliumExpression patternsComplex patternsGenesMolecular determinantsChannel variantsLarge familyChick basilar papillaPhenotypic heterogeneityBasilar papillaChannel isoforms