2020
Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction
Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. Human Pathology 2020, 105: 67-73. PMID: 32941964, PMCID: PMC11152084, DOI: 10.1016/j.humpath.2020.08.007.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsBile refluxIntestinal metaplasiaReactive gastropathyGEJ regionMucosal injuryMucosal changesGastroesophageal junctionAntral intestinal metaplasiaDistal esophageal adenocarcinomaDetailed clinical historySex-matched patientsGastric antral biopsiesAnti-inflammatory drugsGastric bile refluxMucosal inflammationProximal stomachDistal esophagusMedication usePancreatic metaplasiaPathology databaseProximal gastricAntral biopsiesClinical historyGastric biopsiesUpdates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy
Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.Peer-Reviewed Original ResearchConceptsNeoadjuvant therapyEsophageal cancerEsophageal carcinomaRecent American Joint CommitteePreoperative neoadjuvant therapyThorough pathologic assessmentTumor regression gradingAdvanced esophageal carcinomaAmerican Joint CommitteeCancer (AJCC) staging systemTumor regression gradeAccurate tumor stagingValuable prognostic informationRegression gradingSurgical resectionLymph nodesPathologic assessmentRegression gradeHistologic typePathologic evaluationResidual tumorPoor prognosisCell carcinomaGastrointestinal carcinomasStaging systemCryptic Cachexia
Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.Peer-Reviewed Original Research
2019
Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis
Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2019, 44: 241-246. PMID: 31498179, DOI: 10.1097/pas.0000000000001369.Peer-Reviewed Original ResearchConceptsHigh-grade tumor buddingAdverse histologic featuresMalignant polypsNodal metastasisTumor buddingHistologic featuresLymphovascular invasionNode metastasisLymph node metastatic potentialMargin statusSubsequent resectionColectomy specimenColectomy proceduresDifferentiated clustersTumor differentiationOdds ratioRisk featuresMetastasisMetastatic potentialPiecemeal polypectomyPolypsRiskInvasionColectomyResection
2018
Gastric Adenocarcinoma of the Fundic Gland Type
Benedict MA, Lauwers GY, Jain D. Gastric Adenocarcinoma of the Fundic Gland Type. American Journal Of Clinical Pathology 2018, 149: 461-473. PMID: 29648578, DOI: 10.1093/ajcp/aqy019.Peer-Reviewed Original ResearchConceptsFundic gland typeGA-FGGastric adenocarcinomaParietal cellsEndoscopic mucosal resectionGeneral surgical pathologistsFeatures of malignancyChief cell differentiationGland typeDeeper invasionExtragastric spreadGastric atrophyLymphovascular invasionBenign courseIntestinal metaplasiaMucosal resectionNodal metastasisSurgical excisionChronic gastritisRare lesionsUncommon neoplasmHelicobacter infectionOxyntic mucosaSurgical pathologistsAdequate treatment
2017
Massive Gastric Juvenile Polyposis
Lawless ME, Toweill DL, Jewell KD, Jain D, Lamps L, Krasinskas AM, Swanson PE, Upton MP, Yeh MM. Massive Gastric Juvenile Polyposis. American Journal Of Clinical Pathology 2017, 147: 390-390. PMID: 28340255, DOI: 10.1093/ajcp/aqx015.Peer-Reviewed Original ResearchConceptsGastric juvenile polyposisJuvenile polyposisJuvenile polypsMixed inflammatory infiltrateHigh-grade dysplasiaJuvenile polyposis syndromeAncillary diagnostic testsIntramucosal adenocarcinomaInflammatory infiltrateSecond patientSevere bleedingClinicopathologic featuresIntraepithelial neoplasiaEdematous stromaSevere dysplasiaPolyposis syndromeColumnar epitheliumPolyposisAdenocarcinomaPatientsDiagnostic testsStomachPolypsDysplasiaHypoalbuminemia
2016
HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology
Bartley AN, Washington MK, Ventura CB, Ismaila N, Colasacco C, Benson AB, Carrato A, Gulley ML, Jain D, Kakar S, Mackay HJ, Streutker C, Tang L, Troxell M, Ajani JA. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. Archives Of Pathology & Laboratory Medicine 2016, 140: 1345-1363. PMID: 27841667, DOI: 10.5858/arpa.2016-0331-cp.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBiomarkers, TumorClinical Decision-MakingCombined Modality TherapyDecision TreesDiagnosis, DifferentialEsophageal NeoplasmsEvidence-Based MedicineHumansMedical OncologyMolecular Diagnostic TechniquesMolecular Targeted TherapyMutationNeoplasm GradingNeoplasm StagingPathology, ClinicalReceptor, ErbB-2Societies, MedicalStomach NeoplasmsSystematic Reviews as TopicUnited StatesConceptsAdvanced gastroesophageal adenocarcinomaGastroesophageal adenocarcinomaEvidence-based guidelinesAssessment of HER2Clinical OncologyAmerican SocietyClinical decisionClinical pathologyAmerican PathologistsAccuracy of HER2Initial therapyMorphologic selectionOptimal HER2Combination chemotherapyHER2 statusOnly biomarkerSpecific therapyHER2 testingTumor specimensPatientsHER2Systematic reviewClinical implicationsNeoplastic tissueTherapyHER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma
Bartley AN, Washington MK, Ventura CB, Ismaila N, Colasacco C, Benson AB, Carrato A, Gulley ML, Jain D, Kakar S, Mackay HJ, Streutker C, Tang L, Troxell M, Ajani JA. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma. American Journal Of Clinical Pathology 2016, 146: 647-669. PMID: 28077399, PMCID: PMC6272805, DOI: 10.1093/ajcp/aqw206.Peer-Reviewed Original ResearchConceptsAdvanced gastroesophageal adenocarcinomaGastroesophageal adenocarcinomaEvidence-based guidelinesAssessment of HER2Clinical decisionAmerican SocietyAccuracy of HER2Initial therapyMorphologic selectionOptimal HER2Combination chemotherapyHER2 statusOnly biomarkerSpecific therapyHER2 testingClinical OncologyTumor specimensPatientsHER2Systematic reviewClinical implicationsNeoplastic tissueTherapyClinical pathologyAmerican PathologistsHER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology
Bartley AN, Washington MK, Colasacco C, Ventura CB, Ismaila N, Benson AB, Carrato A, Gulley ML, Jain D, Kakar S, Mackay HJ, Streutker C, Tang L, Troxell M, Ajani JA. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology. Journal Of Clinical Oncology 2016, 35: 446-464. PMID: 28129524, DOI: 10.1200/jco.2016.69.4836.Peer-Reviewed Original ResearchConceptsAdvanced gastroesophageal adenocarcinomaGastroesophageal adenocarcinomaEvidence-based guidelinesAssessment of HER2Clinical OncologyAmerican SocietyClinical decisionClinical pathologyAmerican PathologistsAccuracy of HER2Initial therapyMorphologic selectionOptimal HER2Combination chemotherapyHER2 statusOnly biomarkerSpecific therapyHER2 testingTumor specimensPatientsHER2Systematic reviewClinical implicationsNeoplastic tissueTherapyMetabolic Signature on 18F-FDG PET/CT, HER2 Status, and Survival in Gastric Adenocarcinomas
Celli R, Colunga M, Patel N, Djekidel M, Jain D. Metabolic Signature on 18F-FDG PET/CT, HER2 Status, and Survival in Gastric Adenocarcinomas. Journal Of Nuclear Medicine Technology 2016, 44: 234-238. PMID: 27789750, DOI: 10.2967/jnmt.116.181479.Peer-Reviewed Original ResearchConceptsGastroesophageal junction adenocarcinomaHER2 statusPET/CTHER2 casesF-FDG PET/CTHuman epidermal growth factor 2Metabolic signaturesEpidermal growth factor 2Lymph node metastasisWorse overall survivalHER2-negative casesHistologic signatureOverall survivalGrowth factor 2Junction adenocarcinomaNode metastasisPreoperative parametersTumor histologyGastric adenocarcinomaHER2 overexpressionHigh SUVMedian SUVPathology reportsTumor SUVAggressive form
2013
KRAS Mutations are Associated With Specific Morphologic Features in Colon Cancer
Gunal A, Hui P, Kilic S, Xu R, Jain D, Mitchell K, Robert M, Kenney B. KRAS Mutations are Associated With Specific Morphologic Features in Colon Cancer. Journal Of Clinical Gastroenterology 2013, 47: 509-514. PMID: 23090042, DOI: 10.1097/mcg.0b013e3182703030.Peer-Reviewed Original ResearchConceptsKRAS mutation statusKRAS mutationsSpecific morphologic featuresColon cancerMorphologic featuresMutation statusAnti-epidermal growth factor receptor therapyDNA mismatch repair gene mutationsPeritumoral lymphocytic responseT3-T4 statusStage IV diseaseMismatch repair gene mutationsColon cancer resectionTime of resectionRight-sided locationRepair gene mutationsPearson χ2 testAdenocarcinoma morphologyKRAS testingCancer resectionLymphovascular invasionHistologic featuresReceptor therapyLymphocytic responseHistologic characteristics
2009
Lack of Immunohistochemical Detection of VEGF in Prostate Carcinoma
Kamath A, Helie M, Bifulco CB, Li WW, Concato J, Jain D. Lack of Immunohistochemical Detection of VEGF in Prostate Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2009, 17: 227-232. PMID: 19098681, DOI: 10.1097/pai.0b013e31818f9e7f.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorVEGF expressionBenign glandsMalignant glandsDifferent antigen retrieval techniquesVeterans Health Administration hospitalsEndothelial cellsBenign prostatic hyperplasiaRenal cell carcinomaDifferent antibodiesNonspecific stainingPotential therapeutic targetEndothelial growth factorCell carcinomaProstatic hyperplasiaAntigen retrieval methodAntigen retrieval techniqueFibromuscular stromaAdministration HospitalBreast carcinomaProstatic adenocarcinomaHepatocellular carcinomaProstate carcinomaStudy populationIHC analysis
2005
Composite Glandular and Endocrine Tumors of the Stomach With Pancreatic Acinar Differentiation
Jain D, Eslami-Varzaneh F, Takano AM, Ayer U, Umashankar R, Muller R, Klimstra DS. Composite Glandular and Endocrine Tumors of the Stomach With Pancreatic Acinar Differentiation. The American Journal Of Surgical Pathology 2005, 29: 1524-1529. PMID: 16224221, DOI: 10.1097/01.pas.0000169498.89035.f9.Peer-Reviewed Original ResearchConceptsPancreatic acinar differentiationGlandular componentAbdominal painCytokeratin 20Endocrine tumorsCytokeratin 7Acinar differentiationEndocrine componentElevated serum lipase levelsPerigastric lymph nodesSerum lipase levelsExocrine pancreatic enzymesIntestinal goblet cellsColumnar epithelial cellsGastrointestinal hemorrhageLymph nodesAcute pancreatitisClinicopathologic findingsGastric foveolarLipase levelsPrimary tumorGastric neoplasmsComposite tumorImmunohistochemical stainsPancreatic polypeptide
2000
Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases.
Jain D, Parkash V, Li M, Gill J, Crouch J, Howe G, Tallini G. Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases. Archives Of Pathology & Laboratory Medicine 2000, 124: 1369-72. PMID: 10975941, DOI: 10.5858/2000-124-1369-ebvrda.Peer-Reviewed Original ResearchConceptsGlandular differentiationNasopharyngeal typeUndifferentiated carcinomaEpstein-Barr virus latent membrane proteinEpstein-Barr virus genomeSquamous cell carcinomaLatent membrane proteinVirus RNA detectionCell carcinomaMost tumorsNasopharyngeal carcinomaCarcinomaTumorsRNA detectionUndifferentiated areasNasopharynxSitu hybridizationVirus genomeLight microscopyDifferentiationImmunohistochemistryPositivity