2021
α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers
2008
Biliary and Pancreatic Dysgenesis in Mice Harboring a Mutation in Pkhd1
Gallagher AR, Esquivel EL, Briere TS, Tian X, Mitobe M, Menezes LF, Markowitz GS, Jain D, Onuchic LF, Somlo S. Biliary and Pancreatic Dysgenesis in Mice Harboring a Mutation in Pkhd1. American Journal Of Pathology 2008, 172: 417-429. PMID: 18202188, PMCID: PMC2312372, DOI: 10.2353/ajpath.2008.070381.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBile DuctsBiliary TractBlotting, SouthernBlotting, WesternCiliaDisease Models, AnimalHumansImmunohistochemistryIn Situ HybridizationKidney Tubules, ProximalLiver DiseasesMiceMice, Mutant StrainsMutationPancreatic DiseasesPolycystic Kidney, Autosomal RecessiveReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionConceptsPolycystic kidney diseaseAutosomal recessive polycystic kidney diseaseRecessive polycystic kidney diseaseKidney diseaseMouse modelCommon bile duct dilationBile duct dilationBile duct proliferationAutosomal dominant polycystic kidney diseaseProgressive cyst formationDistal nephron segmentsDominant polycystic kidney diseaseExtrahepatic manifestationsDuct dilationBiliary tractPeriportal fibrosisDuct proliferationBile ductFibrocystic diseaseOrthologous modelPancreatic cystsProximal tubulesMice harboringSusceptibility of tissuesNephron segments
2000
Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases.
Jain D, Parkash V, Li M, Gill J, Crouch J, Howe G, Tallini G. Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases. Archives Of Pathology & Laboratory Medicine 2000, 124: 1369-72. PMID: 10975941, DOI: 10.5858/2000-124-1369-ebvrda.Peer-Reviewed Original ResearchConceptsGlandular differentiationNasopharyngeal typeUndifferentiated carcinomaEpstein-Barr virus latent membrane proteinEpstein-Barr virus genomeSquamous cell carcinomaLatent membrane proteinVirus RNA detectionCell carcinomaMost tumorsNasopharyngeal carcinomaCarcinomaTumorsRNA detectionUndifferentiated areasNasopharynxSitu hybridizationVirus genomeLight microscopyDifferentiationImmunohistochemistryPositivity