2021
Pediatric Hepatocellular Adenomas
Pacheco MC, Torbenson MS, Wu TT, Kakar S, Jain D, Yeh MM. Pediatric Hepatocellular Adenomas. The American Journal Of Surgical Pathology 2021, 45: 1641-1647. PMID: 34148984, PMCID: PMC8608351, DOI: 10.1097/pas.0000000000001763.Peer-Reviewed Original ResearchConceptsHepatocellular adenomaPrepubescent groupPediatric patientsNonsyndromic groupΒ-cateninAdenoma subtypesImmunohistochemical staining profileHepatocellular adenoma subtypesPostpubescent groupClinical characteristicsUnclassified subtypeClinical historySyndromic groupsImmunohistochemical stainingPatientsType adenomasAdenomasSyndromeAge groupsLarger studyStaining profileSubtypesGreater percentageGroupLanguage searchα-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers
2018
Histologic features of autoimmune hepatitis: a critical appraisal
Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Histologic features of autoimmune hepatitis: a critical appraisal. Human Pathology 2018, 82: 51-60. PMID: 30041025, DOI: 10.1016/j.humpath.2018.07.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiopsyChildChild, PreschoolDatabases, FactualEmperipolesisFemaleHepatitis C, ChronicHepatitis, AutoimmuneHepatocytesHumansKupffer CellsLiverLiver CirrhosisLymphocytesMaleMiddle AgedPlasma CellsPredictive Value of TestsReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexYoung AdultConceptsProminent plasma cellsAutoimmune hepatitisHistologic featuresPlasma cellsInflammatory gradePortal tractsScoring systemInitiation of therapySeverity of hepatitisDifferent control groupsChronic hepatitisHepatitis CFibrosis stageStudy groupDisease processHepatitisControl groupHyaline globulesFurther studiesPatientsTractCritical appraisalCellsGradeTypical features
2013
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology 2013, 27: 62-72. PMID: 23807780, DOI: 10.1038/modpathol.2013.114.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdolescentAdultAgedBiomarkers, TumorBiopsyChildChild, PreschoolC-Reactive ProteinDiagnosis, DifferentialDiagnostic ErrorsFemaleFocal Nodular HyperplasiaGlutamate-Ammonia LigaseHumansImmunohistochemistryInflammation MediatorsLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsSerum Amyloid A ProteinYoung AdultConceptsSerum amyloid-associated proteinFocal nodular hyperplasiaAmyloid-associated proteinsInflammatory hepatocellular adenomaNodular hyperplasiaHepatocellular adenomaStaining patternDuctular reactionFibrous stromaFocal nodular hyperplasia casesMap-like patternOverlapping histological featuresGlutamine synthetase stainingHistological featuresProtein immunohistochemistryHyperplasia casesIndeterminate lesionsPositive stainingHyperplasiaDiagnostic utilityAdenomasBlood vesselsFrequent overlapStainingDiagnostic errorsImmunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology 2013, 26: 782-791. PMID: 23348905, DOI: 10.1038/modpathol.2012.243.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, ScirrhousAdultAgedArginaseBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularChi-Square DistributionCholangiocarcinomaDiagnosis, DifferentialDiagnostic ErrorsFemaleGlypicansHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsConceptsScirrhous hepatocellular carcinomaClassical hepatocellular carcinomaHepatocellular carcinomaHepatocellular carcinoma casesGlypican-3Carcinoma casesMarked stromal fibrosisEpithelial cell adhesion moleculeMetastatic adenocarcinomaIntrahepatic cholangiocarcinomaStromal fibrosisCytokeratin 7Needle biopsyFrequent positivityCell adhesion moleculeHepPar-1Immunohistochemical pitfallsMorphological subtypesCarcinomaAdenocarcinomaHepatocellular differentiationCytokeratin 19Erroneous diagnosisReliable markerAdhesion molecules
2012
Quantitative histological‐hemodynamic correlations in cirrhosis
Sethasine S, Jain D, Groszmann RJ, Garcia‐Tsao G. Quantitative histological‐hemodynamic correlations in cirrhosis. Hepatology 2012, 55: 1146-1153. PMID: 22109744, PMCID: PMC3721182, DOI: 10.1002/hep.24805.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiopsyDiagnostic ImagingFemaleHemodynamicsHumansHypertension, PortalLiverLiver CirrhosisMaleMiddle AgedPredictive Value of TestsRetrospective StudiesVenous PressureConceptsSignificant portal hypertensionPortal hypertensionFibrosis areaLiver biopsyCirrhotic nodulesNodule sizeHVPG measurementPortal pressureIndependent predictorsSeptal thicknessFibrous septaBiopsyPathophysiological implicationsCirrhosisHVPGPatientsSemiquantitative analysisNodulesOnly parameterHypertensionNumber of nodules