2019
Clinical utility of genomic analysis in adults with idiopathic liver disease
Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.Peer-Reviewed Original ResearchConceptsIdiopathic liver diseaseUnexplained liver diseaseManagement of adultsWhole-exome sequencingLiver diseaseAdult patientsUnknown etiologyHeterozygous variantsUse of WESAmelioration of dyslipidemiaDaily insulin requirementLeptin replacement therapyUtility of WESChronic liver diseaseNon-alcoholic steatohepatitisAcademic health care centerHealth care centersHomozygous pathogenic variantUnrelated adult patientsNon-oncological diseasesDisease preventive measuresInsulin requirementsLean patientsDevastating complicationLiver aminotransferases
2016
Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis
Boga S, Munoz-Abraham AS, Rodriguez-Davalos MI, Emre SH, Jain D, Schilsky ML. Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis. World Journal Of Hepatology 2016, 8: 659-664. PMID: 27239259, PMCID: PMC4876289, DOI: 10.4254/wjh.v8.i15.659.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisLiver transplantationDonor organsPathogenesis of NAFLDDevelopment of NASHHost factorsSame deceased donorOrthotopic liver transplantationFatty liver diseaseGraft injuryLiver allograftsLiver graftsDeceased donorsLiver diseaseGenetic factorsRole of recipientSteatohepatitisTransplantationRecipientsOrgansSLTUnique modelAllograftsPatients