2012
Inflammatory Disorders of the Large Intestine
Jain D, Warren B, Riddell R. Inflammatory Disorders of the Large Intestine. 2012, 552-635. DOI: 10.1002/9781118399668.ch35.Peer-Reviewed Original ResearchChronic inflammatory bowel diseaseAcute infectious colitisLarge intestinal biopsiesInflammatory bowel diseaseInfection-related conditionsMain infectious agentsDiagnosis of dysplasiaDiagnosis of inflammationInfectious colitisTransplant recipientsVariety of virusesBowel diseaseIntestinal biopsiesInflammatory lesionsInflammatory disordersChronic conditionsDisease burdenEnteric infectionsDifferential diagnosisFrequent causeRare diseaseSpecific diagnosisInfectious agentsImmune systemLarge intestine
2010
Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice
Orabi AI, Shah AU, Ahmad MU, Choo-Wing R, Parness J, Jain D, Bhandari V, Husain SZ. Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice. AJP Gastrointestinal And Liver Physiology 2010, 299: g196-g204. PMID: 20448143, PMCID: PMC2904115, DOI: 10.1152/ajpgi.00498.2009.Peer-Reviewed Original ResearchMeSH KeywordsAmylasesAnimalsApoptosisCalcium Channel BlockersCalcium SignalingCeruletideCytoprotectionDantroleneDisease Models, AnimalEnzyme ActivationFluorescent Antibody TechniqueIn Situ Nick-End LabelingMaleMiceMice, Inbred C57BLMicroscopy, ElectronPancreasPancreatitisRyanodine Receptor Calcium Release ChannelSeverity of Illness IndexTime FactorsTrypsinConceptsPancreatic trypsin activityCaerulein-induced pancreatitisRyanodine receptorAcinar cellsMouse pancreatic sectionsHigh-risk settingsTUNEL-positive cellsLater time pointsRyR inhibitor dantroleneDantrolene pretreatmentHistological severityAcute pancreatitisPancreatic acinar cellsInflammatory disordersProphylactic treatmentRyR inhibitionSerum amylasePancreatitis inductionPancreatic sectionsPancreatitisAdequate treatmentTrypsin activityEarly markerCaerulein hyperstimulationUltrastructural derangements