2022
Alternative lengthening of telomeres in primary hepatic neoplasms
Yasir S, Thompson S, Chen Z, Knudson R, Knutson D, Kloft-Nelson S, Graham R, Jain D, Simon S, Wu T, Torbenson M. Alternative lengthening of telomeres in primary hepatic neoplasms. Human Pathology 2022, 131: 79-86. PMID: 36370823, PMCID: PMC10756352, DOI: 10.1016/j.humpath.2022.11.003.Peer-Reviewed Original ResearchConceptsPrimary hepatic neoplasmsPrimary hepatic angiosarcomaHepatocellular carcinomaHepatic neoplasmsHepatic angiosarcomaFibrolamellar carcinomaEpithelial tumorsNuclear pleomorphismFrequency of ALTStromal-epithelial tumorPrimary hepatic tumorsHepatocellular carcinoma componentMarked nuclear pleomorphismSoft tissue tumorsRare carcinosarcomaEmbryonal sarcomaEpithelioid hemangioendotheliomaDuct adenomaHilar cholangiocarcinomaCarcinoma componentHepatic adenomaHepatic tumorsTissue tumorsHepatocellular adenomaRhabdoid tumor
2019
Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma
Balitzer D, Joseph NM, Ferrell L, Shafizadeh N, Jain D, Zhang X, Yeh M, di Tommaso L, Kakar S. Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma. Modern Pathology 2019, 32: 1486-1494. PMID: 31186529, DOI: 10.1038/s41379-019-0290-0.Peer-Reviewed Original ResearchConceptsCholangiolocellular carcinomaIntrahepatic cholangiocarcinomaLow-grade cytologic atypiaPrimary liver carcinomaCapture-based next-generation sequencingCanals of HeringNumber alterationsHistologic subtypeCarcinoma componentCytologic atypiaImmunohistochemistry resultsCholangiocarcinomaLiver carcinomaCarcinomaSelect intronsCell subtypesStem cell subtypesHepatocellular componentDistinct entityMutational profileSubtypesNext-generation sequencingCD56Genomic profilesCD117