2008
Redundant Mechanisms for Dendritic Cell Activation in GVHD Induction: Signalings Via TLRs, TNF-α, IL-1 and CD40 Are Not Required
Li H, Matte-Martone C, Demetris A, McNiff J, Jain D, Shlomchik W. Redundant Mechanisms for Dendritic Cell Activation in GVHD Induction: Signalings Via TLRs, TNF-α, IL-1 and CD40 Are Not Required. Blood 2008, 112: 3509. DOI: 10.1182/blood.v112.11.3509.3509.Peer-Reviewed Original ResearchHost antigen-presenting cellsAntigen-presenting cellsToll-like receptorsDC maturation signalsDonor T cellsDendritic cellsT cellsT cell activationMaturation signalsCell activationGVHD inductionHistologic GVHDMyD88/DC maturationAPC maturationIL-1Alloreactive donor T cellsAlloreactive T cell activationAdaptive T cell responsesAllogeneic stem cell transplantationHost hematopoietic cellsTNFR1/R2WT B6 miceDendritic cell activationT cell primingEffects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 2008, 111: 5242-5251. PMID: 18285547, PMCID: PMC2384145, DOI: 10.1182/blood-2007-09-107953.Peer-Reviewed Original ResearchConceptsSecondary lymphoid tissuesT cellsMemory phenotype CD4 T cellsEffector memory T cellsAllogeneic stem cell transplantationHost disease inductionCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsT cell traffickingGVHD initiationMild GVHDHost diseaseTransplant recipientsTumor effectCell transplantationLymphoid tissueGVHDDisease inductionImmune responseCD62LCCR7Major causeGraftCD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL
Matte-Martone C, Liu J, Jain D, McNiff J, Shlomchik WD. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 2008, 111: 3884-3892. PMID: 18223170, PMCID: PMC2275040, DOI: 10.1182/blood-2007-11-125294.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalGraft vs Host DiseaseGraft vs Leukemia EffectHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceMice, KnockoutMinor Histocompatibility AntigensReceptors, Antigen, T-CellStem Cell TransplantationTransplantation ChimeraTransplantation, HomologousConceptsCD4 cellsT cellsT cell antigen receptorAllogeneic stem cell transplantationMajor histocompatibility complex class IDirect cytolytic actionDistinct effector mechanismsDonor CD4 cellsDonor T cellsStem cell transplantationHistocompatibility complex class IMinor H antigensClass II moleculesComplex class IHost diseaseBCR-ABL cDNAGVHDEffector mechanismsMouse modelCML cellsBone marrowCognate interactionNoncytolytic pathwaysCD8Cytolytic action
2004
Distinct Roles for Donor and Host Antigen Presenting Cells and Costimulatory Molecules in Murine Chronic Graft-Vs-Host Disease: Requirements Depend on Target Organ.
Anderson B, McNiff J, Jain D, Blazar B, Shlomchik W, Shlomchik M. Distinct Roles for Donor and Host Antigen Presenting Cells and Costimulatory Molecules in Murine Chronic Graft-Vs-Host Disease: Requirements Depend on Target Organ. Blood 2004, 104: 3059. DOI: 10.1182/blood.v104.11.3059.3059.Peer-Reviewed Original ResearchChronic GVHDCutaneous chronic GVHDHost APCsCD4 cellsWT BMDonor APCsAcute GVHDHost diseaseRecipient APCsAPC requirementsHost antigen presenting cellsAllogeneic stem cell transplantationChronic Graft-vsDonor CD4 cellsPre-transplant weightDonor T cellsStem cell transplantationCostimulatory molecules CD80Antigen presenting cellsSite of diseaseChimeric recipientsCutaneous GVHDDonor BMGraft-vsGVHD preventionDistinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ
Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 2004, 105: 2227-2234. PMID: 15522961, DOI: 10.1182/blood-2004-08-3032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, CDB7-1 AntigenB7-2 AntigenBone Marrow TransplantationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalGraft vs Host DiseaseIntestinal DiseasesMembrane GlycoproteinsMiceMice, Inbred BALB COrgan SpecificitySkin DiseasesTransplantation, HomologousConceptsHost antigen-presenting cellsAntigen-presenting cellsDonor antigen-presenting cellsChronic GVHDAcute GVHDHost diseaseAPC requirementsHost-derived antigen-presenting cellsAllogeneic stem cell transplantationMurine chronic graftCD8 T cellsStem cell transplantationChronic graftGVHD therapyCell transplantationChronic formCostimulatory moleculesGVHDT cellsTarget organsAPC functionCD80/86Pathogenesis mechanismsCD4GraftTarget Antigens Determine Graft-versus-Host Disease Phenotype
Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target Antigens Determine Graft-versus-Host Disease Phenotype. The Journal Of Immunology 2004, 173: 5467-5475. PMID: 15494494, DOI: 10.4049/jimmunol.173.9.5467.Peer-Reviewed Original ResearchConceptsHost diseaseSkin diseasesBALB/c recipientsAllogeneic stem cell transplantationBALB/c miceSubset of patientsStem cell transplantationT cell repertoireKey pathologic featuresBALB/cX BALB/Host disease phenotypesCutaneous cGVHDMurine donorsSystemic GVHDC recipientsFrequent complicationCutaneous fibrosisPathologic featuresSystemic diseaseB miceCell transplantationC miceK miceImmunodominant Ag