1997
A Basic Motif in the N-Terminal Region of RAG1 Enhances V(D)J Recombination Activity
McMahan C, Difilippantonio M, Rao N, Spanopoulou E, Schatz D. A Basic Motif in the N-Terminal Region of RAG1 Enhances V(D)J Recombination Activity. Molecular And Cellular Biology 1997, 17: 4544-4552. PMID: 9234712, PMCID: PMC232308, DOI: 10.1128/mcb.17.8.4544.Peer-Reviewed Original ResearchConceptsBasic amino acid motifN-terminal regionSite-specific DNA recognitionRecombination activityCell-specific componentsComponent gene segmentsExtrachromosomal recombination substratesAmino acid motifsAmino acids 216Site-specific recombination reactionAntigen receptor genesEvolutionary conservationNuclear transportRAG2 proteinsRAG1 proteinRecombination functionsRecombination substratesDeletion analysisDNA recognitionEnzymatic machineryAcid motifFurther mutagenesisSRP-1N-terminusRAG1
1996
rag-1 and rag-2: Biochemistry and Protein Interactions
Schatz D, Leu T. rag-1 and rag-2: Biochemistry and Protein Interactions. Current Topics In Microbiology And Immunology 1996, 217: 11-29. PMID: 8787615, DOI: 10.1007/978-3-642-50140-1_2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRAG-1Protein-protein interactionsRAG-2 proteinT-cell receptor proteinsSite-specific recombination reactionLymphocyte-specific factorsProtein interactionsEnzymatic machineryGene productsRAG-2Lymphocyte developmentReceptor proteinBiochemical propertiesProteinCoordinated activityGenesTerminal deoxynucleotidyl transferaseRecombinationDiversityDeoxynucleotidyl transferaseMost componentsMachineryNucleotidesSpeciesTransferase