2021
Adaptive Policies to Balance Health Benefits and Economic Costs of Physical Distancing Interventions during the COVID-19 Pandemic
Yaesoubi R, Havumaki J, Chitwood MH, Menzies NA, Gonsalves G, Salomon JA, Paltiel AD, Cohen T. Adaptive Policies to Balance Health Benefits and Economic Costs of Physical Distancing Interventions during the COVID-19 Pandemic. Medical Decision Making 2021, 41: 386-392. PMID: 33504258, PMCID: PMC8084913, DOI: 10.1177/0272989x21990371.Peer-Reviewed Original ResearchConceptsAdaptive policiesClear decision rulesSocial costsEconomic costsPolicy makersPhysical distancing policiesDecision toolPolicyPhysical distancing interventionsDistancing policiesModel-based experimentsDecision rulesReal-time surveillance dataCostCOVID-19 pandemicMakersShorter overall durationMore complex modelsHealth benefitsComplex modelsPandemicCurrent pandemicCOVID-19BenefitsRules
2019
A Value of Information Analysis of Research on the 21-Gene Assay for Breast Cancer Management
Kunst NR, Alarid-Escudero F, Paltiel AD, Wang SY. A Value of Information Analysis of Research on the 21-Gene Assay for Breast Cancer Management. Value In Health 2019, 22: 1102-1110. PMID: 31563252, PMCID: PMC7343670, DOI: 10.1016/j.jval.2019.05.004.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerObservational studyBreast cancerLow-risk early-stage breast cancerHormone receptor-positive early-stage breast cancerPredictive valueLow-risk womenProspective observational studyHigh-risk womenRetrospective observational studyBreast cancer managementQuality-adjusted life yearsCost-effectiveness findingsTraditional risk predictionAdjuvant chemotherapyChemotherapy useAlternative study designsOncotype DXCancer managementClinical utilityCurrent evidenceInsufficient evidenceLife yearsRoutine useStudy design
2012
Model Parameter Estimation and Uncertainty Analysis
Briggs AH, Weinstein MC, Fenwick EA, Karnon J, Sculpher MJ, Paltiel AD. Model Parameter Estimation and Uncertainty Analysis. Medical Decision Making 2012, 32: 722-732. PMID: 22990087, DOI: 10.1177/0272989x12458348.Peer-Reviewed Original ResearchConceptsDecision uncertaintyCost-effectiveness acceptability curvesHealth care resource allocationEconomic evidence basePoint estimatesReporting of uncertaintyAcceptability curvesLevel of uncertaintyPolicy perspectivePerfect informationPrecise point estimatesPresentational techniquesDecision makersDecision modelingResource allocationParameter uncertaintiesBetter decisionsStructural uncertaintyDecisionsModel purposeUncertaintyInformation analysisModel-based analysisExtensive recommendationsStochastic uncertaintyModel Parameter Estimation and Uncertainty: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6
Briggs AH, Weinstein MC, Fenwick EA, Karnon J, Sculpher MJ, Paltiel AD, Force I. Model Parameter Estimation and Uncertainty: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6. Value In Health 2012, 15: 835-842. PMID: 22999133, DOI: 10.1016/j.jval.2012.04.014.Peer-Reviewed Original ResearchConceptsDecision uncertaintyCost-effectiveness acceptability curvesHealth care resource allocationEconomic evidence basePoint estimatesReporting of uncertaintyAcceptability curvesLevel of uncertaintyPolicy perspectivePerfect informationPrecise point estimatesPresentational techniquesDecision makersDecision modelingResource allocationParameter uncertaintiesBetter decisionsStructural uncertaintyDecisionsModel purposeUncertaintyInformation analysisModel-based analysisExtensive recommendationsStochastic uncertainty
2009
Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis
Suter LG, Fraenkel L, Losina E, Katz JN, Gomoll AH, Paltiel AD. Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis. Arthritis & Rheumatism 2009, 61: 1531-1538. PMID: 19877094, PMCID: PMC2804854, DOI: 10.1002/art.24893.Peer-Reviewed Original ResearchConceptsArthroscopic partial meniscectomyMeniscal tearsKnee painInternational Knee Documentation Committee scoreMagnetic resonance imaging (MRI) indicatorsObtainable clinical informationDegenerative meniscal tearsIndividuals ages 45Mean incremental gainIKDC scoreNonoperative managementAge 45Preoperative informationPartial meniscectomyClinical informationOsteoarthritisPainTearsLower likelihoodHigher likelihoodAlternative thresholdsMedical decisionsScoresIncremental gainPatients
1998
A Monte Carlo Simulation of Advanced HIV Disease
Paltiel AD, Scharfstein JA, Seage GR, Losina E, Goldie SJ, Weinstein MC, Craven DE, Freedberg KA. A Monte Carlo Simulation of Advanced HIV Disease. Medical Decision Making 1998, 18: s93-s105. PMID: 9566470, DOI: 10.1177/0272989x98018002s11.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsIncremental cost-effectiveness ratioMonte Carlo simulation frameworkDecision makersCost-effectiveness ratioQuality-adjusted monthsPrice assumptionsNet costLife yearsData estimatesCost-effective usePatient care resourcesState transition modelCare resourcesMakersAdvanced HIV diseaseSensitivity analysisLate-stage diseaseBaseline resultsAlternative interventionsQuality of lifeTreatment of AIDSCostCMV prophylaxisGanciclovir prophylaxis
1996
Mathematical programming for the efficient allocation of health care resources
Stinnett A, Paltiel A. Mathematical programming for the efficient allocation of health care resources. Journal Of Health Economics 1996, 15: 641-653. PMID: 10164046, DOI: 10.1016/s0167-6296(96)00493-6.Peer-Reviewed Original ResearchConceptsGeneral mathematical programming frameworkMathematical programming frameworkMathematical programmingOptimization techniquesRestrictive assumptionsProgramming frameworkExplicit identificationEfficient allocationResource allocation processConstraintsBudget constraintsAllocation processAllocationProgrammingAssumption