2016
Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report
Merola J, Yoo PS, Schaub J, Smith JD, Rodriguez-Davalos MI, Tichy E, Mulligan DC, Asch W, Formica R, Kashgarian M, Kulkarni S. Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report. Transplantation Proceedings 2016, 48: 3106-3108. PMID: 27932157, DOI: 10.1016/j.transproceed.2016.04.005.Peer-Reviewed Original ResearchConceptsCalcineurin inhibitorsHemolytic uremic syndromeThrombotic microangiopathyKidney transplantationUremic syndromeMinimization of CNIsAtypical hemolytic uremic syndromeWithdrawal of tacrolimusEarly graft lossFavorable clinical courseGraft dysfunctionGraft lossImmunosuppression strategiesUsual therapyClinical courseCase reportCTLA-4Endothelial reactionFrequent causeChallenging causeUncontrolled activationMonoclonal antibodiesCellular destructionMicroangiopathyComponent C5
2011
Monoclonal Gammopathy of Undetermined Significance Does Not Affect Outcomes in Patients Undergoing Solid Organ Transplants
Jimenez-Zepeda VH, Heilman RL, Engel RA, Carey EJ, Freeman C, Rakela J, Mulligan DC, Fonseca R, Stewart AK. Monoclonal Gammopathy of Undetermined Significance Does Not Affect Outcomes in Patients Undergoing Solid Organ Transplants. Transplantation 2011, 92: 570-574. PMID: 21712755, DOI: 10.1097/tp.0b013e318225db2c.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlood Protein ElectrophoresisChildDisease ProgressionFemaleHumansImmunosuppression TherapyLymphoproliferative DisordersMaleMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaRisk FactorsTransplantation ImmunologyTransplantsTreatment OutcomeYoung AdultConceptsSolid organ transplant patientsPosttransplant lymphoproliferative disorderOrgan transplant patientsTransplant patientsLymphoproliferative disordersMultiple myelomaUndetermined significanceMonoclonal gammopathyPlasma cell proliferative disorderLiver transplant candidatesOutcomes of patientsCase of progressionSolid organ transplantsPlasma cell dyscrasiaCell proliferative disorderMGUS patientsTransplant candidatesClinical courseLate malignancyLifelong riskImmune suppressionRelative riskCell dyscrasiaMonoclonal clonesOrgan transplants