2008
Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics
Yu Y, Shu Y, McCormick DA. Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics. Journal Of Neuroscience 2008, 28: 7260-7272. PMID: 18632930, PMCID: PMC2664555, DOI: 10.1523/jneurosci.1613-08.2008.Peer-Reviewed Original ResearchConceptsAxon initial segmentAction potentialsAction potential backpropagationAction potential outputAction potential responsesThreshold variabilityInitial segmentCortical neuronsSynaptic activitySynaptic inputsSomatic recordingsCortical ensemblesSensorimotor integrationRate variabilityAction potential eventsSpike initiationAmplitude-time courseTime courseHigh rateTrial variabilityNeurons
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barragesModulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2003
Turning on and off recurrent balanced cortical activity
Shu Y, Hasenstaub A, McCormick D. Turning on and off recurrent balanced cortical activity. Nature 2003, 423: 288-293. PMID: 12748642, DOI: 10.1038/nature01616.Peer-Reviewed Original ResearchConceptsCerebral cortexLocal cortical circuitsCortical neuronsNeuronal excitabilitySynaptic inputsCortical circuitsSpontaneous activityCortical activitySynaptic connectionsRecurrent excitationCortical organizationCortexNeuronsLocal recurrent connectionsRecurrent activitySelf-sustained activityHypothesized roleInhibitionVast majorityActivityExcitabilityExcitatoryAdaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neuronsElectrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses
Nowak L, Azouz R, Sanchez-Vives M, Gray C, McCormick D. Electrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses. Journal Of Neurophysiology 2003, 89: 1541-1566. PMID: 12626627, DOI: 10.1152/jn.00580.2002.Peer-Reviewed Original ResearchConceptsAction potentialsElectrophysiological classesCortical neuronsIntrinsic burstingPrimary visual cortical neuronsShort-duration action potentialsCortical neuronal functionSpiny stellate cellsRegular spikingSpiny stellate neuronsVisual cortical neuronsFrequency adaptationCat area 17High-frequency burstsSpike frequency adaptationCH neuronsTonic trainsNonpyramidal cellsIB neuronsRS neuronsStellate neuronsPyramidal cellsArea 17FS neuronsStellate cellsCellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
Compte A, Sanchez-Vives M, McCormick D, Wang X. Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model. Journal Of Neurophysiology 2003, 89: 2707-2725. PMID: 12612051, DOI: 10.1152/jn.00845.2002.Peer-Reviewed Original ResearchConceptsSlow oscillatory activityOscillatory activityUp statesSpontaneous spike dischargeMinority of neuronsSlow-wave sleepStrong recurrent excitationSpike dischargesTonic firingCerebrospinal fluidDown statePharmacological manipulationRecurrent excitationCortical network modelSlow adaptation currentBiophysical network modelInput resistancePhysiological effectsSlow oscillationsPatchy connectionsInhibition blocksVivo dataNeuronsSingle neuron behaviorBath solution
2000
Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
Brumberg J, Nowak L, McCormick D. Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons. Journal Of Neuroscience 2000, 20: 4829-4843. PMID: 10864940, PMCID: PMC6772270, DOI: 10.1523/jneurosci.20-13-04829.2000.Peer-Reviewed Original ResearchConceptsLayer II/III pyramidal neuronsHigh-frequency burst dischargesAction potential generationAction potentialsPyramidal neuronsCortical neuronsBurst dischargesHigh-frequency burst firingVisual cortical slicesAction potential burstsFirst action potentialBurst-firing modeHigh-frequency burstsPotential generationIonic mechanismsIntrinsic burstsCortical slicesLocal cortical networksBurst firingNeocortical neuronsIntracellular recordingsPostsynaptic neuronsATX IIQX-314Single spiking
1996
Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex
Gray C, McCormick D. Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex. Science 1996, 274: 109-113. PMID: 8810245, DOI: 10.1126/science.274.5284.109.Peer-Reviewed Original ResearchConceptsPyramidal neuronsVisual stimulationSuperficial pyramidal neuronsSubset of neuronsIntracellular recordingsSpontaneous activityGamma frequency bandRhythmic firingGamma-band activityVisual cortexCortical oscillationsNeuronsRepetitive burstsCortexIntracortical contributionsSuperficial layersStimulationMembrane potentialFunctional significanceCellsLarge populationSynchronous oscillationsResponse
1993
Neurotransmitter Control of Neocortical Neuronal Activity and Excitability
McCormick D, Wang Z, Huguenard J. Neurotransmitter Control of Neocortical Neuronal Activity and Excitability. Cerebral Cortex 1993, 3: 387-398. PMID: 7903176, DOI: 10.1093/cercor/3.5.387.Peer-Reviewed Original ResearchConceptsActivation of muscarinicMetabotropic receptorsPyramidal cellsLayers II/IIISingle spike activityGlutamate metabotropic receptorsDuration of EPSPsAction potential generationSpike frequency adaptationCurrent IAHPGABAergic neuronsCortical neuronsGABAA receptorsNMDA receptorsH2-histaminergicNeurotransmitter systemsNeurons resultsSerotoninergic receptorsCortical circuitsNeuronal activityNeurotransmitter controlNeuronal circuitsNeocortical neuronal activityAlpha 1Functional activation