2024
Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning
Martin K, Papadoyannis E, Schiavo J, Fadaei S, Issa H, Song S, Valencia S, Temiz N, McGinley M, McCormick D, Froemke R. Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning. Nature Neuroscience 2024, 1-15. PMID: 39284963, DOI: 10.1038/s41593-024-01767-4.Peer-Reviewed Original ResearchVagus nerve stimulationCentral cholinergic systemNerve stimulationEfficacy of vagus nerve stimulationCholinergic systemVagus nerve stimulation electrodesExperience-dependent plasticityAuditory cortical responsesPeripheral nerve stimulationCholinergic modulationAuditory discrimination taskClinical conditionsTwo-photon imagingCortical responsesCentral mechanismsCholinergic axonsStimulationEnhance task performanceNeural activityOptogenetic experimentsDiscrimination taskDiscrimination abilityEnhances perceptual learningPerceptual learningTask performance
2021
Vagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions