2002
Neuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
1998
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
Kim U, McCormick D. The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus. Journal Of Neuroscience 1998, 18: 9500-9516. PMID: 9801387, PMCID: PMC6792899, DOI: 10.1523/jneurosci.18-22-09500.1998.Peer-Reviewed Original ResearchConceptsAction potentialsThalamocortical neuronsPostsynaptic neuronsDorsal lateral geniculate nucleus (dLGN) neuronsLateral geniculate nucleus neuronsDual intracellular recordingsTonic firing modesLow-threshold Ca2Single action potentialHigh-frequency burstsAction potential generationPerigeniculate neuronsTonic trainsCell typesMembrane potentialNucleus neuronsBurst dischargesIntracellular recordingsGeneration of Ca2Synaptic transmissionPresynaptic cellTemporal summationEpileptic seizuresSynchronized rhythmic oscillationsSynaptic interactions