2021
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
Nestvogel D, McCormick D. Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations. Neuron 2021, 110: 120-138.e4. PMID: 34687663, PMCID: PMC8815448, DOI: 10.1016/j.neuron.2021.10.005.Peer-Reviewed Original ResearchConceptsState-dependent activityAlpha-like rhythmVisual thalamusAwake animalsMovement-related activationHz oscillationsPrimary visual cortexLow-threshold CaThalamic neuronsMovement-related signalsIntracellular recordingsThalamocortical cellsThalamocortical mechanismsCell-intrinsic propertiesVisual cortexThalamocortical interactionsBehavioral statesThalamusNeural mechanismsAlpha oscillationsNeuronsDistinct patternsV1Movement signalsRhythm
1992
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick D, von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2774-2778. PMID: 1313567, PMCID: PMC48745, DOI: 10.1073/pnas.89.7.2774.Peer-Reviewed Original ResearchConceptsSlow-wave sleepCerebral cortexThalamic neuronsRelay neuronsWave sleepLateral geniculate relay neuronsProlonged excitatory postsynaptic potentialGeniculate relay neuronsLayer VI cellsExcitatory postsynaptic potentialsThalamic relay neuronsSensory informationSingle-spike modeBrainstem inputsPostsynaptic potentialsCorticothalamic fibersSlow depolarizationObligatory relayState-dependent mannerSensory transferThalamusMammalian thalamusPotassium conductanceProlonged enhancementNeuronsChapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators
MCCORMICK D, STROWBRIDGE B, HUGUENARD J. Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators. 1992, 259-290. DOI: 10.1016/b978-0-12-484815-3.50017-7.Peer-Reviewed Original ResearchState-dependent processingRelay neuronsSingle neuron propertiesHyperpolarization-activated cation currentNeuron propertiesThalamic relay neuronsAction potential generationThalamic neuronsCentral neuronsRhythmic burstsNervous systemCation currentSynaptic connectionsPacemaker currentThalamusNeuronsMotor informationPotential generationNeuromodulatorsFunctional consequences
1990
Functional implications of burst firing and single spike activity in lateral geniculate relay neurons
McCormick D, Feeser H. Functional implications of burst firing and single spike activity in lateral geniculate relay neurons. Neuroscience 1990, 39: 103-113. PMID: 2089273, DOI: 10.1016/0306-4522(90)90225-s.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsAction potentialsSingle-spike modeThalamic neuronsPostsynaptic potentialsRelay neuronsRhythmic burstsExcitatory inputsLateral geniculate relay neuronsGeniculate relay neuronsPhasic excitatory inputPeripheral receptive fieldsSingle spike activityPeriods of drowsinessLow-threshold Ca2Slow-wave sleepThalamocortical relay neuronsIncoming excitatory inputsHigh-frequency burstsFiring modesNeuronal activityWave sleepSpike activityThreshold Ca2Neurons
1989
Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMP
1988
Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro
McCormick D, Prince D. Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. Journal Of Neurophysiology 1988, 59: 978-996. PMID: 3367206, DOI: 10.1152/jn.1988.59.3.978.Peer-Reviewed Original ResearchConceptsSlow depolarizationElectrophysiological actionsPT neuronsGuinea pigsSlow membrane timeSpike frequency accommodationApplication of norepinephrineSingle spike activityMedial geniculate nucleusExtracellular potassium concentrationCat thalamic neuronsLarge afterhyperpolarizationSlow afterdepolarizationSlow afterhyperpolarizationAnteroventral nucleusCerebral cortexFrequency accommodationThalamic neuronsThalamocortical rhythmsThalamic nucleiGeniculate nucleusIntracellular recordingsNoradrenergic modulationSynaptic transmissionThalamic slices