1987
Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones.
McCormick D, Prince D. Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones. The Journal Of Physiology 1987, 393: 743-762. PMID: 2895811, PMCID: PMC1192421, DOI: 10.1113/jphysiol.1987.sp016851.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronesPost-natal developmentImmature neuronesAction potentialsPyramidal neuronesCortical layer V pyramidal neuronsElectrophysiological propertiesRat sensorimotor cortical slicesLayer V pyramidal neuronsDependent action potentialsApparent input resistanceSensorimotor cortical slicesThird week postPyramidal neuronsCortical slicesIntracellular recordingsWeek postCortical neuronesNeuronesInput resistanceAdult neuronesLonger durationSpecific membrane resistanceInward rectificationAge
1986
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick D, Prince D. Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro. The Journal Of Physiology 1986, 375: 169-194. PMID: 2879035, PMCID: PMC1182754, DOI: 10.1113/jphysiol.1986.sp016112.Peer-Reviewed Original ResearchConceptsNon-pyramidal cellsSlow excitatory responsesPyramidal neuronesMechanism of actionAction potentialsExcitatory responsesInhibitory responsesACh applicationGuinea pig cerebral cortexLayer V pyramidal cellsInhibitory post-synaptic potentialsGABAergic synaptic transmissionRelease of GABAShort-latency excitationSlow depolarizing responseApparent input resistanceACh-induced hyperpolarizationApplication of acetylcholineGamma-aminobutyric acidGuinea pig neocortexPost-synaptic potentialsAverage reversal potentialBarrages of excitatoryMinimum onset latencyAction potential generation