2021
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
Nestvogel D, McCormick D. Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations. Neuron 2021, 110: 120-138.e4. PMID: 34687663, PMCID: PMC8815448, DOI: 10.1016/j.neuron.2021.10.005.Peer-Reviewed Original ResearchConceptsState-dependent activityAlpha-like rhythmVisual thalamusAwake animalsMovement-related activationHz oscillationsPrimary visual cortexLow-threshold CaThalamic neuronsMovement-related signalsIntracellular recordingsThalamocortical cellsThalamocortical mechanismsCell-intrinsic propertiesVisual cortexThalamocortical interactionsBehavioral statesThalamusNeural mechanismsAlpha oscillationsNeuronsDistinct patternsV1Movement signalsRhythm
2019
Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance
Neske G, Nestvogel D, Steffan P, McCormick D. Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance. Journal Of Neuroscience 2019, 39: 10044-10059. PMID: 31672787, PMCID: PMC6978938, DOI: 10.1523/jneurosci.1226-18.2019.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexSensory processingVisual detection performanceCortical neuronal responsesCortical sensory processingWhole-cell recordingsMouse visual systemSensory cortical activityNeuronal membrane potentialArousal levelNeuronal responsivenessFunction of arousalMice increasesNeuronal responsesCortical activityV1 responsesVisual detection taskCortexSensory stimuliSensory responsesLocomotion periodsVisual stimuliBehavioral performanceMembrane potential
2010
Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2007
Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generation
2005
Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17. Journal Of Neuroscience 2005, 25: 1866-1880. PMID: 15716423, PMCID: PMC6725929, DOI: 10.1523/jneurosci.3897-04.2005.Peer-Reviewed Original ResearchConceptsHigh-contrast stimulationMembrane potential hyperpolarizationPotential hyperpolarizationCat primary visual cortexRole of synapticIntrinsic membrane propertiesPrimary visual cortexCat area 17Significant reductionHigh-contrast stimuliGray screenArea 17Synaptic mechanismsLack of stimulationVisual cortexArtificial scotomaRF sizeReceptive field dynamicsSine-wave gratingsSingle neuronsStimulationStrong visual stimuliHigh-contrast sine-wave gratingsHyperpolarizationVisual stimuli
2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neurons
2000
Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo
Sanchez-Vives M, Nowak L, McCormick D. Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo. Journal Of Neuroscience 2000, 20: 4267-4285. PMID: 10818163, PMCID: PMC6772627, DOI: 10.1523/jneurosci.20-11-04267.2000.Peer-Reviewed Original ResearchConceptsPrimary visual cortexContrast adaptationDorsal lateral geniculate nucleus (dLGN) neuronsVisual cortexLateral geniculate nucleus neuronsCat primary visual cortexAction potential activityHigh-contrast visual stimulusIntrinsic neuronal mechanismsMembrane potentialApparent membrane conductanceVisual cortex cellsVisual stimuliLow-contrast stimuliNeuronal responsivenessDLGN cellsNucleus neuronsCortical neuronsIntracellular recordingsIntracellular injectionNeuronal activityReduced responsivenessSynaptic barragesNeuronal mechanismsFiring rateCellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro
Sanchez-Vives M, Nowak L, McCormick D. Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro. Journal Of Neuroscience 2000, 20: 4286-4299. PMID: 10818164, PMCID: PMC6772630, DOI: 10.1523/jneurosci.20-11-04286.2000.Peer-Reviewed Original ResearchConceptsSpike frequency adaptationSlow afterhyperpolarizationCortical neuronsFerret primary visual cortexProlonged dischargeCellular mechanismsVisual cortical neuronsPrimary visual cortexSlow spike frequency adaptationIntracellular recordingsIntracellular injectionRightward shiftAfterhyperpolarizationVisual cortexReversal potentialContrast adaptationNeuronsDischarge frequencyMembrane conductanceVivoVisual systemBlockadeCortexImportant role
1993
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang Z, McCormick D. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD. Journal Of Neuroscience 1993, 13: 2199-2216. PMID: 8386756, PMCID: PMC6576582, DOI: 10.1523/jneurosci.13-05-02199.1993.Peer-Reviewed Original ResearchConceptsIntracellular recordingsMetabotropic receptorsPyramidal cellsLayer V pyramidal cellsGlutamate metabotropic receptor agonistLayer V cellsMetabotropic receptor agonistApplication of norepinephrineAlpha-agonist phenylephrineBeta-antagonist propranololSingle spike activityMuscarinic antagonist scopolamineBeta-agonist isoprenalinePrimary visual cortexAction potential generationSingle-spike modeACh effectsMuscarinic subtypesNE responseInterburst frequencyMuscarinic agonistsReceptor agonistBath applicationPostsynaptic responsesAntagonist scopolamine