2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2002
Inhibitory Interactions Between Ferret Thalamic Reticular Neurons
Shu Y, McCormick D. Inhibitory Interactions Between Ferret Thalamic Reticular Neurons. Journal Of Neurophysiology 2002, 87: 2571-2576. PMID: 11976393, DOI: 10.1152/jn.00850.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsNRT neuronsPostsynaptic potentialsThalamocortical activityReceptor-mediated inhibitory postsynaptic potentialsSpontaneous inhibitory postsynaptic potentialsImportant inhibitory inputThalamic excitatory inputsThalamic reticular nucleusInhibitory interactionsThalamic reticular neuronsThalamic relay nucleiAverage reversal potentialLocal inhibitory interactionsThalamocortical functionNRT cellsReceptor antagonistReticular neuronsReticular nucleusExcitatory inputsIntracellular recordingsInhibitory inputsRelay nucleiExtracellular recordingsNeuronsNeuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
1999
Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus
von Krosigk M, Monckton J, Reiner P, McCormick D. Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus. Neuroscience 1999, 91: 7-20. PMID: 10336055, DOI: 10.1016/s0306-4522(98)00557-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexElectric StimulationExcitatory Postsynaptic PotentialsFemaleGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGuinea PigsMaleMembrane PotentialsNerve FibersNeuronsReceptors, GABA-AReceptors, GABA-BReceptors, Metabotropic GlutamateReticular FormationRetinaThalamusConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsSlow excitatory postsynaptic potentialMonosynaptic excitatory postsynaptic potentialsDorsal lateral geniculate nucleusGlutamate metabotropic receptorsPostsynaptic potentialsLateral geniculate nucleusThalamocortical neuronsCorticothalamic fibersMetabotropic receptorsGeniculate nucleusRepetitive activationRepetitive stimulationReceptor-mediated inhibitory postsynaptic potentialsGABAergic inhibitory postsynaptic potentialsExcitatory postsynaptic potential amplitudeFrequency-dependent decrementFrequency-dependent depressionAspartate glutamate receptorsPostsynaptic potential amplitudeFrequency-dependent facilitationFrequency-dependent increaseOptic tract fibersCorticothalamic afferents
1997
Functional Dynamics of GABAergic Inhibition in the Thalamus
Kim U, Sanchez-Vives M, McCormick D. Functional Dynamics of GABAergic Inhibition in the Thalamus. Science 1997, 278: 130-134. PMID: 9311919, DOI: 10.1126/science.278.5335.130.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineDendritesFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidIn Vitro TechniquesLysineNeuronsOrganophosphorus CompoundsPatch-Clamp TechniquesPresynaptic TerminalsReceptors, GABA-AReceptors, GABA-BSynaptic TransmissionThalamic NucleiConceptsInhibitory postsynaptic potentialsGABAergic inhibitionThalamic reticularThalamocortical networkLow-frequency tonic dischargeGABAergic inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusPatterns of activityLateral geniculate nucleusSlow-wave sleepPerigeniculate neuronsTonic dischargeGABAB receptorsThalamocortical neuronsPerigeniculate cellsPostsynaptic potentialsGABAA receptorsGeniculate nucleusThalamocortical cellsNeuronsGeneration of activityReceptorsReticularDistinct patternsInhibitionModulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro
Lee K, McCormick D. Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro. Neuroscience 1997, 77: 335-350. PMID: 9472394, DOI: 10.1016/s0306-4522(96)00481-2.Peer-Reviewed Original ResearchConceptsSpindle wave generationInhibitory postsynaptic potentialsThalamocortical neuronsLocal applicationTonic dischargeSpindle wavesPostsynaptic potentialsPerigeniculate nucleusGlutamate metabotropic receptor agonistMetabotropic receptor agonistMembrane depolarizationEffects of neurotransmittersSlow-wave sleepPerigeniculate neuronsLeak potassium currentGABAergic cellsGABAergic neuronsLateral geniculateReceptor agonistTonic activityWave sleepPotassium currentThalamic networkACPDNeurons
1996
Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices
Destexhe A, Bal T, McCormick D, Sejnowski T. Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal Of Neurophysiology 1996, 76: 2049-2070. PMID: 8890314, DOI: 10.1152/jn.1996.76.3.2049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBicucullineCalciumCalcium ChannelsElectrophysiologyFerretsGABA AntagonistsIn Vitro TechniquesIon ChannelsKineticsMembrane PotentialsModels, NeurologicalNeural Networks, ComputerPotassium ChannelsRecruitment, NeurophysiologicalRefractory Period, ElectrophysiologicalReticular FormationSynapsesThalamusUp-RegulationConceptsInhibitory postsynaptic potentialsExcitatory postsynaptic potentialsSlow inhibitory postsynaptic potentialFerret thalamic slicesActivity-dependent upregulationTC cellsRE cellsPostsynaptic potentialsThalamic slicesGABAergic inhibitory postsynaptic potentialsSpindle oscillationsCalcium-sensitive currentGABAB inhibitory postsynaptic potentialsLocal axonal arborizationsThalamic reticular neuronsGamma-aminobutyric acidRE neuronsGABAB receptorsIsoxazolepropionic acidRebound burstsReticular neuronsTC neuronsGABAA inhibitionAxonal arborizationBurst discharges
1995
Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
McCormick D, Trent F, Ramoa A. Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei. Journal Of Neuroscience 1995, 15: 5739-5752. PMID: 7643215, PMCID: PMC6577643, DOI: 10.1523/jneurosci.15-08-05739.1995.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLow-threshold Ca2PGN neuronsIntracellular recordingsAction potentialsSpindle wavesPostnatal developmentGABAA receptorsRelay cellsElectrophysiological propertiesGABAA antagonist bicuculline methiodideHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusSpindle wave generationNetwork oscillationsDorsal lateral geniculateAction potential firingLateral geniculate nucleusThalamocortical relay cellsSynchronized network oscillationsBarrages of EPSPsLGNd relay cellsHigh-frequency burstsRole of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro.
Bal T, von Krosigk M, McCormick D. Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. The Journal Of Physiology 1995, 483: 665-685. PMID: 7776250, PMCID: PMC1157809, DOI: 10.1113/jphysiol.1995.sp020613.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsPGN cellsSpindle wave generationLow-threshold Ca2Perigeniculate nucleusSpindle wavesPGN neuronsPostsynaptic potentialsRelay neuronsGABAA receptorsRelay cellsHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusNon-NMDA receptorsShort-duration inhibitory postsynaptic potentialMarked increaseLateral geniculate nucleusExtracellular recording techniquesVitro. 2GABAergic neuronsGABAergic receptorsGABAB receptorsProgressive hyperpolarizationSynaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.
Bal T, von Krosigk M, McCormick D. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal Of Physiology 1995, 483: 641-663. PMID: 7776249, PMCID: PMC1157808, DOI: 10.1113/jphysiol.1995.sp020612.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLGNd relay cellsLateral geniculate nucleusPerigeniculate nucleusRelay cellsGABAB receptorsSpindle wavesPGN neuronsGeniculate nucleusBicuculline-sensitive inhibitory postsynaptic potentialsExcitatory amino acid transmissionDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret lateral geniculate nucleusAmino acid transmissionReversal potentialIntracellular recording techniquesLow-threshold Ca2Vitro. 2Mean reversal potentialSingle-unit activityLocal electrical stimulationKCl-filled microelectrodesPharmacological antagonismBicuculline methiodide
1993
A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons
Destexhe A, McCormick D, Sejnowski T. A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophysical Journal 1993, 65: 2473-2477. PMID: 8312485, PMCID: PMC1225988, DOI: 10.1016/s0006-3495(93)81297-9.Peer-Reviewed Original ResearchConceptsReticular cellsReticular thalamic cellsInhibitory postsynaptic potentialsIntrinsic oscillatory propertiesReticularis neuronsSpindle rhythmicityPostsynaptic potentialsInhibitory synapsesThalamic cellsThalamic relayThalamocortical cellsSilent periodSynaptic interactionsSpindle oscillationsRhythmic oscillationsCellsCellular Mechanisms of a Synchronized Oscillation in the Thalamus
von M, Bal T, McCormick D. Cellular Mechanisms of a Synchronized Oscillation in the Thalamus. Science 1993, 261: 361-364. PMID: 8392750, DOI: 10.1126/science.8392750.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsSpindle wavesPostsynaptic potentialsAbsence seizuresRelay cellsFerret lateral geniculate nucleusRhythmic population activityGABAB inhibitory postsynaptic potentialsReceptor-mediated inhibitionSeizure-like activityLateral geniculate nucleusGABAB receptorsRebound burstsGABAB antagonistRelay neuronsPerigeniculate nucleusGeniculate nucleusPharmacological blockNeuronal activityCortical systemsCellular mechanismsPopulation activitySeizuresCellsThalamus
1989
GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick D. GABA as an inhibitory neurotransmitter in human cerebral cortex. Journal Of Neurophysiology 1989, 62: 1018-1027. PMID: 2573696, DOI: 10.1152/jn.1989.62.5.1018.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsGamma-aminobutyric acidEarly inhibitory postsynaptic potentialHuman cerebral cortexExcitatory postsynaptic potentialsAverage reversal potentialCerebral cortexInhibitory neurotransmitterPostsynaptic potentialsLate inhibitory postsynaptic potentialsSlow inhibitory postsynaptic potentialGABAergic inhibitory postsynaptic potentialsInitial excitatory postsynaptic potentialsReversal potentialGABAB agonist baclofenGABAB antagonist phaclofenGABAA antagonist bicucullineGABAA agonist muscimolParoxysmal epileptiform activityMajor inhibitory neurotransmitterVitro. 2Antagonist phaclofenMembrane conductanceAgonist baclofenAntagonist bicuculline
1988
Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus
McCormick D, Pape H. Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus. Nature 1988, 334: 246-248. PMID: 3398922, DOI: 10.1038/334246a0.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusRelay cellsGeniculate nucleusDorsal lateral geniculate nucleusMuscarinic receptor-mediated increaseBrainstem cholinergic neuronsCat lateral geniculate nucleusInhibitory postsynaptic potentialsReceptor-mediated increaseDistinctive electrophysiological propertiesUnderlying ionic mechanismsLGNd relay cellsAcetylcholine inhibitsCholinergic neuronsAcetylcholine releaseCerebral cortexCholinergic actionCholinergic axonsPostsynaptic potentialsRelay neuronsCholinergic systemFacilitatory influenceElectrophysiological propertiesCat LGNdIntrageniculate interneurons