2001
ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES
McCormick D, Contreras D. ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES. Annual Review Of Physiology 2001, 63: 815-846. PMID: 11181977, DOI: 10.1146/annurev.physiol.63.1.815.Peer-Reviewed Original ResearchConceptsCerebral cortexEpileptic seizuresSynchronized burstsRhythmic burst dischargesSpike-wave activityIntrinsic membrane propertiesForm of seizuresPeriod of hyperpolarizationLoss of balanceRecurrent excitatory connectionsEpileptic syndromesSeizure dischargesPyramidal neuronsTonic depolarizationEpileptiform activitySeizure generationBurst dischargesInhibitory neuronsInhibitory influenceInterictal spikesNormal brain rhythmsSynaptic plasticityAction potentialsSeizuresMammalian forebrain
1997
Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro
Sanchez-Vives M, McCormick D. Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro. Journal Of Neuroscience 1997, 17: 8880-8893. PMID: 9348355, PMCID: PMC6573089, DOI: 10.1523/jneurosci.17-22-08880.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAnticonvulsantsBaclofenBicucullineCerebral CortexConvulsantsElectrophysiologyFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesMaleMembrane PotentialsNeural InhibitionNeural PathwaysNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticThalamic NucleiConceptsGABAB receptorsThalamocortical neuronsPGN neuronsGABAA receptorsThalamocortical cellsGABAB receptor-mediated IPSPsLocal applicationDorsal lateral geniculate nucleusReceptor-mediated IPSPsSynchronous slow oscillationsLow-intensity stimulationLow-threshold Ca2Lateral geniculate nucleusStrong activationPerigeniculate nucleusGeniculate nucleusIntracellular recordingsInhibitory influenceAction potentialsIntensity stimulationThreshold Ca2IPSPsNeuronsSpindle wavesPathological conditions