2005
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
2000
Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
Brumberg J, Nowak L, McCormick D. Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons. Journal Of Neuroscience 2000, 20: 4829-4843. PMID: 10864940, PMCID: PMC6772270, DOI: 10.1523/jneurosci.20-13-04829.2000.Peer-Reviewed Original ResearchConceptsLayer II/III pyramidal neuronsHigh-frequency burst dischargesAction potential generationAction potentialsPyramidal neuronsCortical neuronsBurst dischargesHigh-frequency burst firingVisual cortical slicesAction potential burstsFirst action potentialBurst-firing modeHigh-frequency burstsPotential generationIonic mechanismsIntrinsic burstsCortical slicesLocal cortical networksBurst firingNeocortical neuronsIntracellular recordingsPostsynaptic neuronsATX IIQX-314Single spikingCorticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networks
1993
Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.
Bal T, McCormick D. Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker. The Journal Of Physiology 1993, 468: 669-691. PMID: 8254530, PMCID: PMC1143849, DOI: 10.1113/jphysiol.1993.sp019794.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Nucleus reticularis thalamiRhythmic burst firingThreshold Ca2Reticularis thalamiBurst firingExtracellular Ca2Action potentialsOscillatory activityShort-latency burstsSingle spike activityVitro. 2Fast action potentialsNon-selective cationSlow ADPThalamic afferentsTonic dischargeNRT cellsIntracellular recordingsIntracellular injectionSpike AHPsSpike activitySingle neuronesExtracellular applicationReversal potential
1987
Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.
McCormick D, Prince D. Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro. The Journal Of Physiology 1987, 392: 147-165. PMID: 2833597, PMCID: PMC1192298, DOI: 10.1113/jphysiol.1987.sp016774.Peer-Reviewed Original ResearchConceptsRapid excitatory responseSlow depolarizationApplication of acetylcholineLateral geniculate nucleusGeniculate nucleusMuscarinic hyperpolarizationExcitatory responsesMuscarinic receptorsReversal potentialDorsal lateral geniculate nucleusGeniculate neuronesApparent input conductanceSingle spike activityIntracellular recording techniquesAction of acetylcholineACh-induced hyperpolarizationExtrapolated reversal potentialSingle-spike firingMechanism of actionMembrane potentialBath applicationBurst firingBurst dischargesSynaptic transmissionThalamic slices