Featured Publications
Community factors associated with local epidemic timing of respiratory syncytial virus: A spatiotemporal modeling study
Zheng Z, Pitzer VE, Warren JL, Weinberger DM. Community factors associated with local epidemic timing of respiratory syncytial virus: A spatiotemporal modeling study. Science Advances 2021, 7: eabd6421. PMID: 34162556, PMCID: PMC8221622, DOI: 10.1126/sciadv.abd6421.Peer-Reviewed Original ResearchRespiratory syncytial virusEpidemic timingSyncytial virusRSV epidemicsBayesian meta-regression modelTiming of deliveryMaternal vaccinesMeta-regression modelsHospitalization dataLarge burdenEarly epidemicLarger household sizeYoung childrenTransmission dynamicsZip code levelEpidemicCommunity factorsEpidemic spreadFuture studiesVirusProphylaxisMorbidityVaccineFactors
2024
Workshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV
Prunas O, Willemsen J, Warren J, Bont L, Schwartz J, Atwell J, Begier E, Dean N, Hirsch I, Karron R, Klugman K, Kramer R, Leidman E, Link-Gelles R, Nair H, Panozzo C, Pelfrene E, Simões E, Smith P, Srikantiah P, Sundaram M, Thindwa D, Vaughn D, Wilson E, Zar H, Pitzer V, Weinberger D. Workshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV. Vaccine X 2024, 19: 100509. DOI: 10.1016/j.jvacx.2024.100509.Peer-Reviewed Original ResearchRespiratory syncytial virusRandomized controlled trialsPreventive therapyPrevention of respiratory syncytial virusTrial designSuccess of randomized controlled trialsVaccine trial designDesign randomized controlled trialClinical trial designEstimates of vaccine efficacyPrimary endpointSyncytial virusClinical trialsVaccine efficacyControlled trialsMeta-regression modelsSelection of primary endpointsEndpointSequential trial designTherapyMultiple endpointsInteractions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review
Besteman S, Bogaert D, Bont L, Mejias A, Ramilo O, Weinberger D, Dagan R. Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review. The Lancet Respiratory Medicine 2024, 12: 915-932. PMID: 38991585, DOI: 10.1016/s2213-2600(24)00148-6.Peer-Reviewed Original ResearchRespiratory syncytial virusChildhood respiratory infectionsRespiratory infectionsSyncytial virusStreptococcus pneumoniaeRespiratory syncytial virus vaccineLower respiratory tract infectionsRespiratory tract infectionsSystematic reviewGlobal health burdenYears of ageRSV hospitalisationTract infectionsPneumococcal vaccineSevere diseaseGlobal morbidityEpidemiological associationMonoclonal antibodiesPathogen-pathogen interactionsPneumococciInfectionHealth burdenPathogenesisHost modulationApproaches to disease prevention
2023
The full value of immunisation against respiratory syncytial virus for infants younger than 1 year: effects beyond prevention of acute respiratory illness
Feikin D, Karron R, Saha S, Sparrow E, Srikantiah P, Weinberger D, Zar H. The full value of immunisation against respiratory syncytial virus for infants younger than 1 year: effects beyond prevention of acute respiratory illness. The Lancet Infectious Diseases 2023, 24: e318-e327. PMID: 38000374, DOI: 10.1016/s1473-3099(23)00568-6.Peer-Reviewed Original ResearchLower respiratory tract infectionsRespiratory syncytial virusRSV diseaseRespiratory illnessSyncytial virusRespiratory diseaseAcute lower respiratory tract infectionPrevention of RSVAcute respiratory illnessRespiratory tract infectionsImportant public health benefitsInappropriate antibiotic useSevere respiratory illnessCause infant mortalityCost-effective interventionPublic health benefitsHealth care systemMaternal vaccinesRecurrent hospitalisationsRSV preventionSecondary pneumoniaTract infectionsMiddle-income countriesLung healthAntibiotic use
2022
Saliva as an alternative to nasopharyngeal swabs for detection of respiratory syncytial virus (RSV) in children
Langedijk A, Allicock O, Van Wijk M, Yolda-Carr D, Weinberger D, Wyllie A, Bont L. Saliva as an alternative to nasopharyngeal swabs for detection of respiratory syncytial virus (RSV) in children. 2022, 4519. DOI: 10.1183/13993003.congress-2022.4519.Peer-Reviewed Original Research
2021
Estimation of the Timing and Intensity of Reemergence of Respiratory Syncytial Virus Following the COVID-19 Pandemic in the US
Zheng Z, Pitzer VE, Shapiro ED, Bont LJ, Weinberger DM. Estimation of the Timing and Intensity of Reemergence of Respiratory Syncytial Virus Following the COVID-19 Pandemic in the US. JAMA Network Open 2021, 4: e2141779. PMID: 34913973, PMCID: PMC8678706, DOI: 10.1001/jamanetworkopen.2021.41779.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRSV epidemicsMathematical modelRSV hospitalizationRSV seasonSyncytial virusSummer epidemicsRSV lower respiratory tract infectionLower respiratory tract infectionsCOVID-19 pandemicLarge RSV outbreaksMaternal-derived immunityRespiratory tract infectionsChildren 1 yearYears of ageSARS-CoV-2Simulation modeling studyProphylaxis administrationRSV circulationRSV infectionRSV outbreaksSecondary outcomesTract infectionsPrimary outcomeLeading cause
2015
Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data
Weinberger DM, Klugman KP, Steiner CA, Simonsen L, Viboud C. Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data. PLOS Medicine 2015, 12: e1001776. PMID: 25562317, PMCID: PMC4285401, DOI: 10.1371/journal.pmed.1001776.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusPneumococcal pneumoniaRate of hospitalizationPneumococcal diseaseHospitalization dataSeven-valent pneumococcal conjugate vaccineBacterial infectionsRespiratory syncytial virus activityLaboratory-confirmed dataPneumococcal pneumonia hospitalizationsPneumococcal conjugate vaccineIntroduction of PCV7Secondary bacterial infectionState Inpatient DatabasesPoisson regression modelsRSV hospitalizationPCV7 introductionPneumonia hospitalizationsConjugate vaccineInpatient DatabaseSyncytial virusPneumococcal septicemiaPneumonia casesEpidemic timingHospitalization