Daniel F Vatner, MD, PhD
Assistant Professor of Medicine (Endocrinology)Cards
About
Research
Publications
Featured Publications
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions
Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner D, Mehal W, AlcHepNet, Kluger Y, Flavell R. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 2023, 186: 3793-3809.e26. PMID: 37562401, PMCID: PMC10544749, DOI: 10.1016/j.cell.2023.07.017.Peer-Reviewed Original ResearchRising NAFLD and metabolic severity during the Sars‐CoV‐2 pandemic among children with obesity in the United States
Slusher A, Hu P, Samuels S, Tokoglu F, Lat J, Li Z, Alguard M, Strober J, Vatner D, Shabanova V, Caprio S. Rising NAFLD and metabolic severity during the Sars‐CoV‐2 pandemic among children with obesity in the United States. Obesity 2023, 31: 1383-1391. PMID: 36694381, PMCID: PMC10186584, DOI: 10.1002/oby.23728.Peer-Reviewed Original ResearchInsulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchHepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease.
Ter Horst KW, Vatner DF, Zhang D, Cline GW, Ackermans MT, Nederveen AJ, Verheij J, Demirkiran A, van Wagensveld BA, Dallinga-Thie GM, Nieuwdorp M, Romijn JA, Shulman GI, Serlie MJ. Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. Diabetes Care 2020, 44: 489-498. PMID: 33293347, PMCID: PMC7818337, DOI: 10.2337/dc20-1644.Peer-Reviewed Original ResearchAltered Catecholamine Stimulated Adipose Lipolysis Contributes to Hepatic Steatosis in Pnpla3I148M Mice
Golla J, Strober J, Paolella L, Suh R, Zhang F, Philbrick W, Vatner D. Altered Catecholamine Stimulated Adipose Lipolysis Contributes to Hepatic Steatosis in Pnpla3I148M Mice. Cellular And Molecular Gastroenterology And Hepatology 2025, 19: 101500. PMID: 40118273, PMCID: PMC12198021, DOI: 10.1016/j.jcmgh.2025.101500.Peer-Reviewed Original ResearchElevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates
Strober J, Siebel S, Murray S, Rodríguez M, Gonzalez C, Vatner D. Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates. Journal Of Lipid Research 2025, 66: 100838. PMID: 40499904, PMCID: PMC12268660, DOI: 10.1016/j.jlr.2025.100838.Peer-Reviewed Original ResearchAltered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.
Strober J, Ter Horst K, Sung D, Jongejan A, Slusher A, Gassaway B, Tarabra E, Paulo J, Shuken S, Gygi S, Santoro N, Caprio S, Serlie M, Bogan J, Vatner D. Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue. Diabetes 2025, 75: 341-350. PMID: 41347935, PMCID: PMC12823340, DOI: 10.2337/db25-0488.Peer-Reviewed Original ResearchHigh-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis
Goedeke L, Strober J, Suh R, Paolella L, Li X, Rogers J, Petersen M, Nasiri A, Casals G, Kahn M, Cline G, Samuel V, Shulman G, Vatner D. High-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis. IScience 2024, 27: 111175. PMID: 39524330, PMCID: PMC11550620, DOI: 10.1016/j.isci.2024.111175.Peer-Reviewed Original Research
2026
CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity
Sakuma I, Gaspar R, Morgan H, Zheng J, Nasiri A, Dufour S, Kahn M, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Samuel V, Tanaka T, Shulman G. CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity. Cell Reports 2026, 45: 117369. PMID: 42234563, DOI: 10.1016/j.celrep.2026.117369.Peer-Reviewed Original Research
2025
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, PMCID: PMC12067271, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original Research
Teaching & Mentoring
News
News
- April 08, 2026Source: Yale News
Serving Those Who Served: For Many Yale Physicians, Veteran Care Has Become a Mission
- July 29, 2025
Study Reveals Cholesterol’s Role in Fibrotic Progression of Metabolic Liver Disease
- March 25, 2025
Targeting Hormones Could Reduce Risk of Fatty Liver Disease
- April 01, 2021
Insulin Stimulates Production of Body Heat, New Study Finds