2017
PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma
Breen MS, Tylee DS, Maihofer AX, Neylan TC, Mehta D, Binder EB, Chandler SD, Hess JL, Kremen WS, Risbrough VB, Woelk CH, Baker DG, Nievergelt CM, Tsuang MT, Buxbaum JD, Glatt SJ. PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma. Neuropsychopharmacology 2017, 43: 469-481. PMID: 28925389, PMCID: PMC5770765, DOI: 10.1038/npp.2017.220.Peer-Reviewed Original ResearchConceptsDistinct gene expression perturbationsCo-expression network analysisMitogen-activated protein kinase activityCommon signaling cascadesGene expression perturbationsProtein kinase activityTranscriptome-wide screenDistinct biological pathwaysMolecular convergenceGene expression signaturesTranscriptome studiesExpression perturbationsTranscriptional dysregulationSignaling cascadesKinase activityBiological pathwaysExpression signaturesType I interferonWidespread immune dysregulationInnate immuneLipid metabolismPathwayI interferonNetwork analysisDysregulation
2015
Gene networks specific for innate immunity define post-traumatic stress disorder
Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O'Connor DT, Nievergelt CM, Woelk CH. Gene networks specific for innate immunity define post-traumatic stress disorder. Molecular Psychiatry 2015, 20: 1538-1545. PMID: 25754082, PMCID: PMC4565790, DOI: 10.1038/mp.2015.9.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPTSD developmentStress disorderExpression of genesDevelopment of PTSDEarly preventative measuresPeripheral blood leukocytesInnate immune responseProper wound healingProspective experimental designClinical indicatorsRNA-seq gene expressionHemostatic systemBlood leukocytesInnate immuneCausal pathophysiologyMechanisms of PTSDCo-regulated genesInnate immunityPrevious transcriptomic studiesTrauma exposureCo-expression modulesU.S. MarinesPreventative measuresWound healing