2020
Positron Emission Tomography Imaging Evaluation of a Novel 18F‑Labeled Sigma‑1 Receptor Radioligand in Cynomolgus Monkeys
Jia H, Cai Z, Holden D, He Y, Lin SF, Li S, Baum E, Shirali A, Kapinos M, Gao H, Ropchan J, Huang Y. Positron Emission Tomography Imaging Evaluation of a Novel 18F‑Labeled Sigma‑1 Receptor Radioligand in Cynomolgus Monkeys. ACS Chemical Neuroscience 2020, 11: 1673-1681. PMID: 32356969, DOI: 10.1021/acschemneuro.0c00171.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainFluorine RadioisotopesMacaca fascicularisPositron-Emission TomographyRadiopharmaceuticalsReceptors, sigma
2010
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
Roberts B, Holden D, Shaffer C, Seymour P, Menniti F, Schmidt C, Williams G, Castner S. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behavioural Brain Research 2010, 212: 41-48. PMID: 20347881, DOI: 10.1016/j.bbr.2010.03.039.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnalysis of VarianceAnimalsAnimals, NewbornArea Under CurveDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleExcitatory Amino Acid AgonistsKetamineMacaca fascicularisMacaca mulattaMemory DisordersMemory, Short-TermMotor ActivityNeuropsychological TestsReaction TimeSulfonamidesThiophenesTime FactorsConceptsCognitive impairment associated with schizophreniaAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acidMemory impairmentN-methyl-D-aspartateCognitive dysfunctionCore aspect of schizophreniaEffects of acute ketamineBehavioral effects of ketaminePositive modulators of AMPA receptorsEffects of positive allosteric modulatorsModel of cognitive dysfunctionAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptorsNegative-like symptomsWorking memory deficitsWorking memory impairmentModulation of AMPA receptorsEffects of ketaminePositive allosteric modulatorsRegulation of NMDA receptorsGlutamatergic synaptic transmissionAcute ketamineWorking memoryPF-4778574Antagonist ketamineMemory deficits