2016
Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK‐6577 in baboons
Zheng MQ, Lin SF, Holden D, Naganawa M, Ropchan JR, Najafzaden S, Kapinos M, Tabriz M, Carson RE, Hamill TG, Huang Y. Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK‐6577 in baboons. Synapse 2016, 70: 112-120. PMID: 26671330, DOI: 10.1002/syn.21879.Peer-Reviewed Original ResearchAnimalsBenzamidesBrainBrain MappingCarbon RadioisotopesChromatography, High Pressure LiquidDrug Evaluation, PreclinicalFemaleGlycine AgentsGlycine Plasma Membrane Transport ProteinsKineticsLinear ModelsMagnetic Resonance ImagingMolecular StructurePapioPositron-Emission TomographyRadiopharmaceuticalsSulfonamides
2015
Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm
Xia Y, Zheng MQ, Holden D, Lin SF, Kapinos M, Ropchan J, Gallezot JD, Huang Y, Carson RE. Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 2001-2009. PMID: 26198176, PMCID: PMC4671121, DOI: 10.1038/jcbfm.2015.163.Peer-Reviewed Original ResearchConceptsGlycine transporter-1 inhibitorNew positron emission tomography radiotracerPositron emission tomography (PET) radiotracerPotential therapeutic agentNondisplaceable distribution volumeNMDA receptorsVivo affinityBaboon brainDistribution volumeBmax valuesTomography radiotracerTherapeutic agentsVivo KDBrainRank orderUnlabeled compoundsRadiotracerKdBrainstem
2010
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
Roberts B, Holden D, Shaffer C, Seymour P, Menniti F, Schmidt C, Williams G, Castner S. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behavioural Brain Research 2010, 212: 41-48. PMID: 20347881, DOI: 10.1016/j.bbr.2010.03.039.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnalysis of VarianceAnimalsAnimals, NewbornArea Under CurveDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleExcitatory Amino Acid AgonistsKetamineMacaca fascicularisMacaca mulattaMemory DisordersMemory, Short-TermMotor ActivityNeuropsychological TestsReaction TimeSulfonamidesThiophenesTime FactorsConceptsCognitive impairment associated with schizophreniaAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acidMemory impairmentN-methyl-D-aspartateCognitive dysfunctionCore aspect of schizophreniaEffects of acute ketamineBehavioral effects of ketaminePositive modulators of AMPA receptorsEffects of positive allosteric modulatorsModel of cognitive dysfunctionAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptorsNegative-like symptomsWorking memory deficitsWorking memory impairmentModulation of AMPA receptorsEffects of ketaminePositive allosteric modulatorsRegulation of NMDA receptorsGlutamatergic synaptic transmissionAcute ketamineWorking memoryPF-4778574Antagonist ketamineMemory deficits