In Vivo Evaluation of 18F-MNI698: An 18F-Labeled Radiotracer for Imaging of Serotonin 4 Receptors in Brain
Tavares AA, Caillé F, Barret O, Papin C, Lee H, Morley TJ, Fowles K, Holden D, Seibyl JP, Alagille D, Tamagnan GD. In Vivo Evaluation of 18F-MNI698: An 18F-Labeled Radiotracer for Imaging of Serotonin 4 Receptors in Brain. Journal Of Nuclear Medicine 2014, 55: 858-864. PMID: 24686782, DOI: 10.2967/jnumed.113.132712.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingDioxanesDose-Response Relationship, RadiationFemaleFluorine RadioisotopesImage Processing, Computer-AssistedKineticsMacaca mulattaMalePiperidinesPositron-Emission TomographyRadiopharmaceuticalsReceptors, Serotonin, 5-HT4Reproducibility of ResultsSerotonin AntagonistsTime FactorsTissue DistributionConceptsBrain disordersPET radiotracersSerotonin 4 receptorBolus intravenous injectionNovel therapeutic approachesMultiple brain disordersAdult rhesus monkeysDifferent brain disordersDose limitDose-dependent mannerPromising PET radiotracerTest-retest variabilityTest-retest measurementsRadiotracer infusionBrain distributionBolus injectionIntravenous injectionArterial bloodTherapeutic approachesHuman studiesBody weightConstant infusionMonkey brainDistribution volumeInvasive methodWhole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [18F]MNI-698
Tavares AA, Caillé F, Barret O, Papin C, Lee H, Morley TJ, Fowles K, Holden D, Seibyl JP, Alagille D, Tamagnan GD. Whole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [18F]MNI-698. Nuclear Medicine And Biology 2014, 41: 432-439. PMID: 24674817, DOI: 10.1016/j.nucmedbio.2014.02.005.Peer-Reviewed Original ResearchConceptsSerotonin 4 receptorWhole-body biodistributionUrinary bladderDosimetry estimatesOLINDA/EXM 1.0 softwareNovel radiotracersEffective doseMSv/MBqIntravenous bolus injectionWhole-body positron emission tomography (PET) imagesHuman clinical trialsFuture clinical protocolsMain elimination routeAdult rhesus monkeysUrinary bladder modelWhole body weightClinical trialsBolus injectionClinical protocolsNew radiotracersRhesus monkeysCritical organsEffective dosesEmission tomography imagesBladder model