Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity
Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsCaloric RestrictionGlutamic AcidGlutamineMaleMitochondriaRatsRats, Inbred F344Synaptic TransmissionConceptsOld CR ratsNeuronal activityYoung controlsCR ratsCaloric restriction (CR) prolongs lifespanHealthy agingNeuronal glucose oxidationBrain mitochondrial functionNeuronal energy productionMitochondrial functionAge-related declineNeurotransmitter cyclingOlder controlsNeurotransmission ratesBrain physiologyRatsGlucose oxidationProlong lifespanVivo nuclear magnetic resonance (NMR) spectroscopyMagnetic resonance spectroscopyDetrimental effectsAgingControl