2014
Lanthanide ion (III) complexes of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS)
Huang Y, Coman D, Ali MM, Hyder F. Lanthanide ion (III) complexes of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS). Contrast Media & Molecular Imaging 2014, 10: 51-58. PMID: 24801742, PMCID: PMC4222994, DOI: 10.1002/cmmi.1604.Peer-Reviewed Original ResearchConceptsChemical exchange saturation transferLanthanide complexesExchangeable protonsProton resonancesPH imagingLanthanide ion complexesRedundant deviationChemical shift differencesChemical exchange saturation transfer contrastCEST contrastIon complexesChemical shiftsQuantitative pH imagingShift differencesSingle-proton resonancesChemical shift imaging methodsMagnetic resonanceCEST experimentsWater protonsNonexchangeable protonsParamagnetic effectSaturation transferBiosensorComplexesWater resonance
2011
A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate
Coman D, Kiefer GE, Rothman DL, Sherry AD, Hyder F. A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate. NMR In Biomedicine 2011, 24: 1216-1225. PMID: 22020775, PMCID: PMC3267016, DOI: 10.1002/nbm.1677.Peer-Reviewed Original ResearchConceptsResponsive contrast agentsChemical exchange saturation transferMolecular imagingNonexchangeable proton resonancesMolecular imaging agentsLanthanide complexesCEST characteristicsIon complexesBiosensing propertiesBulk waterProton exchangeProton resonancesTetraacetate derivativeNonexchangeable protonsQuantitative molecular imagingRedundant deviationExchangeable sitesInner sphereSaturation transferImaging agentCEST methodComplexesIonsContrast agentsGreat potential