2015
Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility
Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM. Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility. Journal Of Neuroscience 2015, 35: 7964-7976. PMID: 25995480, PMCID: PMC4438134, DOI: 10.1523/jneurosci.3884-14.2015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAmygdalaCuesFemaleHumansHungerHypothalamusMalePolymorphism, GeneticReceptors, Dopamine D2SatiationWeight GainConceptsAbsence of hungerWeight changeBasolateral amygdalaLong-term weight changeLong-term weight gainWeight gain susceptibilityGustatory inputD2 receptor densityA1 allele carriersAmygdala responseSated subjectsGhrelin levelsInitial BMILateral hypothalamusHuman hypothalamusAllele carriersReceptor densityAmygdala pathwayHealthy individualsElicit eatingDopamine signalingConfer susceptibilityWeight gainDynamic causal modelingNonhomeostatic eating
2010
Genetically Determined Differences in Brain Response to a Primary Food Reward
Felsted JA, Ren X, Chouinard-Decorte F, Small DM. Genetically Determined Differences in Brain Response to a Primary Food Reward. Journal Of Neuroscience 2010, 30: 2428-2432. PMID: 20164326, PMCID: PMC2831082, DOI: 10.1523/jneurosci.5483-09.2010.Peer-Reviewed Original ResearchConceptsBrain responsesPrimary food rewardFunctional magnetic resonanceTaqIA A1 alleleOrbital frontal cortexReward driveIndividual differencesNeural responsesFuture weight gainFood rewardPalatable foodNeuroimaging techniquesPerceptual responsesBiological underpinningsIndividual factorsFrontal cortexImpulsivityDiminished dopamineSimilar ratingsFood reinforcementRewardSpecific associationNeurophysiologyMilkshakeBody mass index