2016
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Heni M, Kullmann S, Ahlqvist E, Wagner R, Machicao F, Staiger H, Häring HU, Almgren P, Groop LC, Small DM, Fritsche A, Preissl H. Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia 2016, 59: 2622-2631. PMID: 27600277, DOI: 10.1007/s00125-016-4095-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdministration, IntranasalAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHumansInsulinInsulin ResistanceMagnetic Resonance SpectroscopyMaleMiddle AgedObesityPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsInsulin sensitivityReceptor densityCaudate nucleusDopamine D2 receptor densityFTO obesity-risk alleleANKK1 polymorphismCentral insulin sensitivityIntranasal insulin administrationPeripheral insulin sensitivityBrain insulin sensitivityRisk of obesityDopamine receptor densityD2 receptor availabilityObesity risk allelesD2 receptor densityTübingen Family studyMalmö DietWaist circumferenceFTO SNP rs8050136FTO variationInsulin administrationD2 receptorsFood intakeBody fatBody composition
2015
Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility
Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM. Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility. Journal Of Neuroscience 2015, 35: 7964-7976. PMID: 25995480, PMCID: PMC4438134, DOI: 10.1523/jneurosci.3884-14.2015.Peer-Reviewed Original ResearchConceptsAbsence of hungerWeight changeBasolateral amygdalaLong-term weight changeLong-term weight gainWeight gain susceptibilityGustatory inputD2 receptor densityA1 allele carriersAmygdala responseSated subjectsGhrelin levelsInitial BMILateral hypothalamusHuman hypothalamusAllele carriersReceptor densityAmygdala pathwayHealthy individualsElicit eatingDopamine signalingConfer susceptibilityWeight gainDynamic causal modelingNonhomeostatic eating
2011
Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food
Stice E, Yokum S, Burger KS, Epstein LH, Small DM. Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food. Journal Of Neuroscience 2011, 31: 4360-4366. PMID: 21430137, PMCID: PMC3260083, DOI: 10.1523/jneurosci.6604-10.2011.Peer-Reviewed Original ResearchConceptsNormal weight humansObese humansStriatal responsesFood intakeOrbitofrontal cortexDopamine signalingWeight gainInitial vulnerability factorsGenetic riskStriatal D2 receptorsMonetary rewardsNormal-weight adolescentsPalatable food intakeD2 receptor densityD2 receptorsHigh-risk youthParietal operculumReceptor densitySomatosensory regionsPalatable foodFoods contributesFrontal operculumReward circuitryReduced dopamineObesity