Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 2007, 61: 862-865. PMID: 17630673, DOI: 10.1002/syn.20430.Peer-Reviewed Original ResearchConceptsPrenatal exposureFemale ratsSpine synapsesPrelimbic cortexDendritic spinesCognitive deficitsLayers II/IIIPrenatal saline controlsExcitatory synaptic inputsAsymmetric spine synapsesPrenatal cocaine exposureRat prelimbic cortexYoung adult malesPhysical disector methodPyramidal neuronsSaline controlsNeuronal activationCocaine exposureExcitatory synapsesFrontal cortexSynaptic inputsAnimal modelsExcess activationPrefrontal cortexCortex