2008
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszan T, Dow A, Warner-Schmidt JL, Szigeti-Buck K, Sallam NL, Parducz A, Leranth C, Duman RS. Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression. Biological Psychiatry 2008, 65: 392-400. PMID: 19006787, PMCID: PMC2663388, DOI: 10.1016/j.biopsych.2008.09.031.Peer-Reviewed Original ResearchConceptsHippocampal spine synapsesSpine synapse lossSpine synapsesInescapable footshockEscape deficitSynapse lossDepressive behaviorHippocampal synaptic changesLoss of synapsesNonstressed control ratsStress-related disordersElectron microscopic stereologyStructural synaptic modificationsDesipramine treatmentSynaptic alterationsMotor cortexControl ratsDentate gyrusHippocampal dysfunctionMale ratsSingle injectionSynaptic changesHelplessness paradigmBehavioral effectsSynaptic modification
2007
Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats
Leranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T. Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats. Endocrinology 2007, 149: 988-994. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.Peer-Reviewed Original ResearchConceptsAdult male ratsMedial prefrontal cortexMale ratsSpine synapsesCA1 hippocampal areaAsymmetric spine synapsesSham-operated animalsElectron microscopic stereologyImpairs synaptogenesisSynaptogenic actionsOvariectomized ratsHippocampal areaTestosterone supplementationTestosterone propionateEstrogen receptorExposure measurement dataOil vehicleCompensatory increaseIntact animalsSynthetic xenoestrogenPrefrontal cortexRatsHippocampusCastrated malesPotential mechanisms