2008
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszan T, Dow A, Warner-Schmidt JL, Szigeti-Buck K, Sallam NL, Parducz A, Leranth C, Duman RS. Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression. Biological Psychiatry 2008, 65: 392-400. PMID: 19006787, PMCID: PMC2663388, DOI: 10.1016/j.biopsych.2008.09.031.Peer-Reviewed Original ResearchConceptsHippocampal spine synapsesSpine synapse lossSpine synapsesInescapable footshockEscape deficitSynapse lossDepressive behaviorHippocampal synaptic changesLoss of synapsesNonstressed control ratsStress-related disordersElectron microscopic stereologyStructural synaptic modificationsDesipramine treatmentSynaptic alterationsMotor cortexControl ratsDentate gyrusHippocampal dysfunctionMale ratsSingle injectionSynaptic changesHelplessness paradigmBehavioral effectsSynaptic modification
2007
Sex steroids and the dentate gyrus
Hajszan T, Milner TA, Leranth C. Sex steroids and the dentate gyrus. Progress In Brain Research 2007, 163: 399-816. PMID: 17765731, PMCID: PMC1964752, DOI: 10.1016/s0079-6123(07)63023-4.Peer-Reviewed Original ResearchConceptsDentate gyrusSex steroidsGonadal hormonesSynaptic remodelingActivational effectsNormal dentate gyrusExpression of estrogenDentate gyrus neurogenesisCholinergic septohippocampal systemNormal cognitive functionSteroid-mediated actionsMore granule cellsCertain mouse strainsGyrus neurogenesisNeuroprotective potentialDentate neuronsAndrogen receptorGonadal originDentate cellsAdult brainHippocampal formationGranule cellsCellular injuryClinical importanceAlzheimer's diseaseExtrinsic afferent systems to the dentate gyrus
Leranth C, Hajszan T. Extrinsic afferent systems to the dentate gyrus. Progress In Brain Research 2007, 163: 63-799. PMID: 17765712, PMCID: PMC1989689, DOI: 10.1016/s0079-6123(07)63004-0.Peer-Reviewed Original ResearchConceptsDentate gyrusAfferent systemsMedial septum/diagonal bandExtrinsic afferent systemsVentral tegmental areaGranule cell dendritesPopulations of neuronsExtrinsic afferentsNoradrenergic afferentsCholinergic neuronsGlutamatergic innervationLocus ceruleusSerotonergic fibersCommissural afferentsGABAergic interneuronsPostsynaptic targetsEntorhinal afferentsTegmental areaCell dendritesDiagonal bandMedian rapheSupramammillary areaPontine nucleiHippocampal formationAfferents