2023
Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis
Carey G, Holleck J, Alshaeba S, Jayakrishnan R, Gordon K, Grimshaw A, Gunderson C. Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis. Journal Of Antimicrobial Chemotherapy 2023, 78: 1150-1159. PMID: 36964648, DOI: 10.1093/jac/dkad078.Peer-Reviewed Original ResearchConceptsCommon infectious syndromesEmpirical antibioticsPrevalence of MRSAInfectious syndromesMRSA infectionIll patientsMortality rateSystematic reviewAbsolute mortality benefitAnti-MRSA therapyEmpirical antibiotic coverageLow-risk infectionsSoft tissue infectionsUrinary tract infectionAbsolute risk reductionMethicillin-resistant Staphylococcus aureusCatheter-related infectionsStudy of patientsBaseline mortality ratesSystematic literature searchWeb of ScienceMRSA coverageAntibiotic coverageEmpirical antimicrobialsMortality benefit
2016
Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections
Gunderson CG, Holleck JL, Chang JJ, Merchant N, Lin S, Gupta S. Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections. American Journal Of Infection Control 2016, 44: 1176-1177. PMID: 27311510, DOI: 10.1016/j.ajic.2016.03.039.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsMRSA infectionTissue infectionsPrevalence populationsMethicillin-resistant Staphylococcus aureus nasal colonizationMRSA soft tissue infectionsStaphylococcus aureus nasal colonizationHigh-prevalence populationsLow-prevalence populationsPositive likelihood ratioNegative likelihood ratioNasal MRSALikelihood ratioNasal colonizationClinical utilityInfectionDiagnostic accuracyAdmissionHospitalPopulationMRSAPrevalenceClinical characteristics and outcomes of veterans hospitalised with purulent soft tissue infections with and without systemic signs of infection
Gunderson CG, Holleck J, Chang JJ, Lin S, Merchant N, Gupta S. Clinical characteristics and outcomes of veterans hospitalised with purulent soft tissue infections with and without systemic signs of infection. Infectious Diseases 2016, 48: 503-508. PMID: 26950290, DOI: 10.3109/23744235.2016.1154599.Peer-Reviewed Original ResearchConceptsPurulent soft tissue infectionsSoft tissue infectionsTissue infectionsClinical characteristicsSevere sepsisSIRS groupSystemic signsSIR groupSystemic inflammatory response syndrome criteriaBroad Gram-negative activityMethods Retrospective cohort studyOutcomes of veteransAcute kidney injuryRetrospective cohort studyEpisodes of bacteremiaTime of hospitalisationCohort of patientsMajority of patientsMost clinical characteristicsUse of antibioticsMore bacteremiaKidney injuryShorter hospitalisationSyndrome criteriaCohort study
2011
Cellulitis: Definition, Etiology, and Clinical Features
Gunderson CG. Cellulitis: Definition, Etiology, and Clinical Features. The American Journal Of Medicine 2011, 124: 1113-1122. PMID: 22014791, DOI: 10.1016/j.amjmed.2011.06.028.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsClinical featuresTissue infectionsCommunity-associated methicillin-resistant Staphylococcus aureusInfectious Diseases SocietyMethicillin-resistant Staphylococcus aureusDiseases SocietyAntimicrobial recommendationsCommon conditionCellulitisRecent recommendationsStaphylococcus aureusEtiologyInfectionPhysicians