2022
Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation
Chouairi F, Mullan C, Ahmed A, Bhinder J, Guha A, Miller P, Jastreboff A, Fuery M, Chiravuri M, Geirsson A, Desai N, Maulion C, Sen S, Ahmad T, Anwer M. Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation. PLOS ONE 2022, 17: e0273111. PMID: 36516178, PMCID: PMC9750001, DOI: 10.1371/journal.pone.0273111.Peer-Reviewed Original ResearchConceptsPost-transplant mortalityType 2 diabetesAllocation system changeOld allocation systemsHeart transplant recipientsOutcomes of patientsOrgan Sharing databaseProportion of patientsHeart transplantation outcomesLower likelihoodLikelihood of transplantationHigher likelihoodNew allocation systemCardiac transplantationHeart transplantationTransplant recipientsT2D patientsHeart failureSharing databaseCox regressionTransplantation outcomesUnited NetworkWorse outcomesT2DPatients
2021
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsBrief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018
Chouairi F, Mullan CW, Ravindra N, Clark KAA, Jaffe EM, Bhinder J, Fuery M, Guha A, Ahmad T, Desai NR. Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018. PLOS ONE 2021, 16: e0255514. PMID: 34591847, PMCID: PMC8483306, DOI: 10.1371/journal.pone.0255514.Peer-Reviewed Original ResearchEvaluation of Racial and Ethnic Disparities in Cardiac Transplantation
Chouairi F, Fuery M, Clark KA, Mullan CW, Stewart J, Caraballo C, Clarke J, Sen S, Guha A, Ibrahim NE, Cole RT, Holaday L, Anwer M, Geirsson A, Rogers JG, Velazquez EJ, Desai NR, Ahmad T, Miller PE. Evaluation of Racial and Ethnic Disparities in Cardiac Transplantation. Journal Of The American Heart Association 2021, 10: e021067. PMID: 34431324, PMCID: PMC8649228, DOI: 10.1161/jaha.120.021067.Peer-Reviewed Original ResearchConceptsWhite patientsHispanic patientsBlack patientsCardiac transplantationHeart transplantationHigh riskEthnic disparitiesAdult heart recipientsAllocation system changePost-transplant deathPost-transplant mortalityOrgan Sharing databasePost-transplantation deathNew allocation systemHeart recipientsDiabetes mellitusRenal diseaseSharing databaseTransplantation ratesUnited NetworkContemporary outcomesPatientsTransplantationDonor characteristicsStudy periodThe Impact of Depression on Outcomes in Patients With Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial
Chouairi F, Fuery MA, Mullan CW, Caraballo C, Sen S, Maulion C, Wilkinson ST, Surti T, McCullough M, Miller PE, Pacor J, Leifer ES, Felker GM, Velazquez EJ, Fiuzat M, O'Connor CM, Januzzi JL, Desai NR, Ahmad T. The Impact of Depression on Outcomes in Patients With Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial. Journal Of Cardiac Failure 2021, 27: 1359-1366. PMID: 34166799, DOI: 10.1016/j.cardfail.2021.06.008.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyReduced ejection fractionAmino-terminal pro-B-type natriuretic peptide levelsPro-B-type natriuretic peptide levelsGUIDE-IT trialNatriuretic peptide levelsHeart failureEjection fractionClinical outcomesPeptide levelsOptimal guideline-directed medical therapyCox proportional hazards regression modelingProportional hazards regression modelingImpact of depressionHistory of depressionCardiovascular deathCause hospitalizationCause mortalityOverall cohortMedical therapyAdverse outcomesTarget dosesPatientsMental healthTime pointsVariants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease
Yousef S, Singh S, Alkukhun A, Alturkmani B, Mori M, Chen J, Mullan CW, Brooks CW, Assi R, Gruber PJ, Cortopassi I, Geirsson A, Vallabhajosyula P. Variants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease. Journal Of Cardiac Surgery 2021, 36: 2348-2354. PMID: 33855754, DOI: 10.1111/jocs.15563.Peer-Reviewed Original ResearchConceptsAortic arch anomaliesArch anomaliesAneurysm diseaseBovine archAberrant right subclavian arteryAdult populationThoracic aortic aneurysm diseasePrevalence of TAAsRight-sided archRight subclavian arteryCharacteristics of patientsIndependent risk factorAortic valve pathologyAdult general populationGeneral adult populationAortic aneurysm diseaseLogistic regression analysisSingle health systemFisher's exact testOlder adult populationBinary logistic regressionThoracic aortopathiesSubclavian arteryCommon diagnosisThoracic aneurysmImpact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies
Chouairi F, Mullan CW, Sen S, Mori M, Fuery M, Elder RW, Lesse J, Norton K, Clark KA, Miller PE, Mulligan D, Formica R, Rogers JG, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T. Impact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies. PLOS ONE 2021, 16: e0247789. PMID: 33651802, PMCID: PMC7924739, DOI: 10.1371/journal.pone.0247789.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseAllocation system changeHeart allocation systemNew heart allocation policyNew heart allocation systemTransplantation of patientsOrgan Sharing databasePost-transplantation outcomesPost-transplant survivalTime of transplantationMechanical circulatory supportRate of transplantationNumber of patientsHeart allocation policyNew allocation systemStatus 1ACardiac transplantAdult patientsSharing databaseWaitlist survivalCirculatory supportClinical benefitCongenital cardiomyopathyUnited NetworkCHD patientsImpact of chronic lung disease on quality‐of‐life outcomes in patients undergoing transcatheter aortic valve replacement
Catalano MA, Lin D, Mullan CW, Cassiere H, Rutkin B, Maurer G, Berg J, Hartman A, Yu P. Impact of chronic lung disease on quality‐of‐life outcomes in patients undergoing transcatheter aortic valve replacement. Journal Of Cardiac Surgery 2021, 36: 672-677. PMID: 33403744, DOI: 10.1111/jocs.15248.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementChronic lung diseaseAortic valve replacementAortic stenosisLung diseaseValve replacementKansas City Cardiomyopathy Questionnaire-12Concomitant severe aortic stenosisLower baseline ejection fractionPreoperative pulmonary function testsSTS Predicted RiskSevere aortic stenosisBaseline ejection fractionPeripheral artery diseasePulmonary function testsObstructive lung diseaseSignificant differencesKCCQ-12TAVR patientsPostoperative outcomesSymptomatic improvementArtery diseaseEjection fractionRetrospective reviewFunction tests
2020
Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure
Mezzacappa C, Ravindra NG, Caraballo C, Chouairi F, Miller PE, Clarke JD, Gruen J, Mori M, McCullough M, Mullan C, Geirsson A, Rogers JG, Anwer M, Desai N, Ahmad T. Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure. PLOS ONE 2020, 15: e0242928. PMID: 33270648, PMCID: PMC7714148, DOI: 10.1371/journal.pone.0242928.Peer-Reviewed Original ResearchConceptsClinical trialsVentricular assist deviceExclusion criteriaLVAD recipientsAssist deviceReal-world settingClinical implicationsClinical trial exclusion criteriaHeart failure clinical trialsEnd-stage renal diseaseEnd-stage heart failureReal-world registryRetrospective cohort studyLandmark clinical trialsStage renal diseaseTrial exclusion criteriaRisk of deathStage heart failureRespiratory failureCohort studyPatient characteristicsHeart failurePatient factorsRenal diseaseClinical outcomesDrug use associated tricuspid valve infective endocarditis in pregnancy
Lin D, Mullan CW, Deshmukh U, Bahtiyar MO, Hosier H, Lipkind H, Abdel‐Razeq S, Ranjan S, Lancaster G, Pietras C. Drug use associated tricuspid valve infective endocarditis in pregnancy. Journal Of Cardiac Surgery 2020, 35: 2392-2395. PMID: 32720414, DOI: 10.1111/jocs.14888.Peer-Reviewed Original ResearchConceptsDrug useTricuspid valve infective endocarditisWeeks 6 days' gestationAppropriate intravenous antibioticsTricuspid valve endocarditisLife-threatening complicationsIntravenous drug useNeonatal critical careIntravenous antibioticsCesarean deliveryPerioperative periodValve endocarditisCardiac surgeryInfective endocarditisCritical careDays gestationPatient managementPregnant femalesEndocarditisMultidisciplinary collaborationPatientsGestationComplicationsPregnancySurgerySex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure
Gruen J, Caraballo C, Miller PE, McCullough M, Mezzacappa C, Ravindra N, Mullan CW, Reinhardt SW, Mori M, Velazquez E, Geirsson A, Ahmad T, Desai NR. Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 770-779. PMID: 32653446, DOI: 10.1016/j.jchf.2020.04.015.Peer-Reviewed Original ResearchConceptsAdverse eventsVentricular assist deviceClinical outcomesPotential underuseHigh riskAssist deviceEnd-stage heartWomen 65 yearsRisk of deathContinuous-flow LVADYears of ageAdvanced treatment optionsSex differencesHeart transplantationMultivariable adjustmentHeart failureHeart transplantSimilar incidenceTreatment optionsSimilar riskSurvival analysisLVADPatientsDevice malfunctionWomenPsychiatric Comorbidity and Outcomes After Left Ventricular Assist Device Implantation for End-Stage Heart Failure
Mullan C, Caraballo C, Ravindra NG, Miller PE, McCullough M, Brown K, Aw TW, Gruen J, Clarke JD, Velazquez EJ, Geirsson A, Mori M, Desai NR, Ahmad T. Psychiatric Comorbidity and Outcomes After Left Ventricular Assist Device Implantation for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 569-577. PMID: 32535119, DOI: 10.1016/j.jchf.2020.03.011.Peer-Reviewed Original ResearchConceptsPsychiatric comorbidityMajor psychiatric illnessNarcotic dependencePsychiatric illnessAdverse eventsHeart failureAlcohol abuseKansas City Cardiomyopathy Questionnaire scoreDrug useVentricular assist device implantationEnd-stage heart failureMechanically Assisted Circulatory SupportAssist device implantationEnd-stage heartRisk of rehospitalizationContinuous-flow LVADRisk of mortalityVulnerable patient populationVentricular assist deviceDevice-related infectionsInteragency RegistryLVAD recipientsSpecific psychiatric conditionsClinical outcomesPatient selectionClinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation
Mullan C, Caraballo C, Ravindra NG, Miller PE, Mori M, McCullough M, Clarke JD, Anwer M, Velazquez EJ, Geirsson A, Desai NR, Ahmad T. Clinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation. The Journal Of Heart And Lung Transplantation 2020, 39: 926-933. PMID: 32593561, DOI: 10.1016/j.healun.2020.05.007.Peer-Reviewed Original ResearchConceptsConcomitant tricuspid valve proceduresTricuspid valve proceduresSevere tricuspid regurgitationTricuspid regurgitationLVAD implantationValve proceduresLeft ventricular assist device implantationVentricular assist device implantationDegree of TREnd-stage heart failureAssist device implantationRisk of bleedingCases of mildContinuous-flow LVADVentricular assist deviceInteragency RegistryAdult patientsAdverse eventsSurvival benefitHeart failureClinical outcomesDevice implantationTR severityQOL outcomesClinical impactModern Treatment Trends and Outcomes of Pulmonary Embolism With and Without Hemodynamic Significance
Mullan CW, Newman J, Geib M, Pichert MD, Saffarzadeh A, Hartman A, Lima B. Modern Treatment Trends and Outcomes of Pulmonary Embolism With and Without Hemodynamic Significance. The Annals Of Thoracic Surgery 2020, 110: 1534-1540. PMID: 32224241, DOI: 10.1016/j.athoracsur.2020.02.041.Peer-Reviewed Original ResearchConceptsCatheter-directed therapyPulmonary embolismSaddle embolismHospital deathSurgical embolectomySystemic thrombolyticsMembrane oxygenationSaddle pulmonary embolismExtracorporeal membrane oxygenationNational Inpatient SampleNational trendsSystemic thrombolysisPulmonary embolectomyRevision codesInpatient SampleHemodynamic significanceEmbolectomyTreatment trendsEmbolismInternational ClassificationLogistic regressionPopulation-level outcomesTherapyDeathThrombolyticsCombined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair
Faggion Vinholo T, Mori M, Mahmood SUB, Mullan CW, Weininger G, Yousef S, Geirsson A. Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 665-672. PMID: 32060011, DOI: 10.1053/j.semtcvs.2020.02.010.Peer-Reviewed Original ResearchConceptsDouble valve surgeryPerioperative adverse eventsTricuspid valve repairTricuspid regurgitationValve surgeryAdverse eventsValve repairMitral valveMitral positionValve functionTriple valve surgeryMid-term survivalLimited clinical evidenceSingle-institution seriesSubpopulation of patientsTricuspid valve functionMitral valve diseaseValve operationsLogistic regression modelsSignificant additional riskMultivalve surgeryPostoperative echocardiogramsPatient comorbiditiesMultivariable analysisClinical evidence
2019
Clinical Outcomes After Left Ventricular Assist Device Implantation in Older Adults An INTERMACS Analysis
Caraballo C, DeFilippis EM, Nakagawa S, Ravindra NG, Miller PE, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Mullan C, Ali A, Maurer MS, Desai NR, Ahmad T, Topkara VK. Clinical Outcomes After Left Ventricular Assist Device Implantation in Older Adults An INTERMACS Analysis. JACC Heart Failure 2019, 7: 1069-1078. PMID: 31779930, DOI: 10.1016/j.jchf.2019.10.004.Peer-Reviewed Original ResearchConceptsYears of ageVentricular assist device implantationAssist device implantationOlder adultsElderly patientsLVAD implantationDevice implantationMultivariate Cox proportional hazards regression modelCox proportional hazards regression modelKaplan-Meier survival estimatesMechanically Assisted Circulatory SupportProportional hazards regression modelsMechanical circulatory support technologyPost-LVAD outcomesHeart failure populationLog-rank testingSerum albumin levelPredictors of survivalPost-LVAD implantationHazards regression modelsPredictors of outcomeAge-specific outcomesAntithrombotic regimenDurable MCSINTERMACS AnalysisClinical significance of presenting syndromes on outcome after coronary artery bypass grafting
Bin Mahmood SU, Mori M, Yousef S, Mullan CW, Mangi AA, Geirsson A. Clinical significance of presenting syndromes on outcome after coronary artery bypass grafting. Interdisciplinary CardioVascular And Thoracic Surgery 2019, 30: 243-248. PMID: 31713612, DOI: 10.1093/icvts/ivz259.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeStable ischemic heart diseaseCox proportional hazards modelCoronary artery bypassMid-term survivalIschemic heart diseaseProportional hazards modelPresenting syndromeArtery bypassHeart diseaseHazards modelMortality rateMultivariable Cox proportional hazards modelsMultivariate Cox proportional hazards modelMid-term mortality ratesSingle-center retrospective studyConsecutive CABG operationsMid-term mortalityCongestive heart failurePost-discharge survivalLong-term followIntensive care unitOverall mean durationMore comorbiditiesCABG operationsPediatric thymectomy: a study of national trends in demographics, short-term outcomes, and cost
Catalano MA, Mullan CW, Rich BS, Glick RD. Pediatric thymectomy: a study of national trends in demographics, short-term outcomes, and cost. Pediatric Surgery International 2019, 35: 749-757. PMID: 31119357, DOI: 10.1007/s00383-019-04486-1.Peer-Reviewed Original ResearchConceptsShort-term outcomesMyasthenia gravisRetrospective cross-sectional analysisOverall morbidity rateShorter hospital staySingle-institution cohortHospital discharge recordsLength of stayCross-sectional analysisMethodsThe KidsHospital deathHospital stayRespiratory complicationsPatient characteristicsCommon indicationLow morbidityPediatric patientsPediatric populationThymic neoplasmsHispanic raceInpatient DatabaseMorbidity rateMore complicationsSurgical approachRisk factorsUS National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014
Mori M, Mullan CW, Bin Mahmood SU, Yousef S, Pelletier KJ, Mangi AA, Geirsson A. US National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014. Canadian Journal Of Cardiology 2019, 35: 1394-1399. PMID: 31493971, DOI: 10.1016/j.cjca.2019.05.015.Peer-Reviewed Original ResearchConceptsConstrictive pericarditisPatient characteristicsNational Inpatient Sample datasetHospital mortality rateOutcomes of patientsProportion of patientsCardiopulmonary bypass useUS national trendsUse of CPBUS Census population estimatesCensus population estimatesPoisson regression modelsCPB useHospital mortalityOperative mortalityComorbid patientsSurgical managementBypass usePericarditisMortality ratePatientsPericardiectomyCohortNational trendsMortality
2015
Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
Lindesmith LC, Ferris MT, Mullan CW, Ferreira J, Debbink K, Swanstrom J, Richardson C, Goodwin RR, Baehner F, Mendelman PM, Bargatze RF, Baric RS. Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial. PLOS Medicine 2015, 12: e1001807. PMID: 25803642, PMCID: PMC4371888, DOI: 10.1371/journal.pmed.1001807.Peer-Reviewed Original ResearchConceptsTime of vaccinationAb responsesVLP vaccineHuman volunteersProtective immunityAb titersCandidate vaccinesEffective NoV vaccinesPhase I ClinicalCross-strain protectionSurrogate neutralization assayBlockade antibodiesAb blockadeNoV infectionBlockade assayAcute gastroenteritisImmune responseNeutralization assaysNoV vaccinesVaccine componentsPredominant GIIMultiple epitopesVaccinationPrevious exposure historyAntigenic drift