2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potentialPearls and Pitfalls in Pediatric Thyroid Imaging
Silva CT, Navarro OM. Pearls and Pitfalls in Pediatric Thyroid Imaging. Seminars In Ultrasound CT And MRI 2020, 41: 421-432. PMID: 32980089, DOI: 10.1053/j.sult.2020.05.007.Peer-Reviewed Original ResearchConceptsDiffuse thyroid enlargementThyroid enlargementCongenital hypothyroidismThyroid nodulesThyroid imagingPediatric age groupRole of imagingRisk of malignancyPermanent congenital hypothyroidismGraves' diseasePediatric populationHashimoto's diseaseNodular hyperplasiaPapillary carcinomaThyroid glandAccurate diagnosisAge groupsThyroid dysgenesisHypothyroidismDiseaseChildrenTeenage girlsImagingManagement recommendationsEnlargement
2018
Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents
Faustino EVS, Shabanova V, Pinto MG, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Napolitano M, Brudnicki AR, Tala JA, Silva CT, Investigators T, Miksa M, Taragin B, Blickman J, Taillie E, Trakas E, Balasco A, Herliczek T, Polikoff L, Dovi G, Napolitano M, Gertz S, Riordan M, Zasa J, Brudnicki A, Eldridge P, Li S, Pinto M, Faustino E, Silva C, Tala J. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents. The Journal Of Pediatrics 2018, 201: 176-183.e2. PMID: 29891258, DOI: 10.1016/j.jpeds.2018.05.006.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisExtremity deep venous thrombosisIll adolescentsVenous thrombosisFrequency of DVTLower extremity deep venous thrombosisCases of DVTBilateral deep venous thrombosisPediatric intensive care unitInvasive mechanical ventilationCentral venous catheterizationIntensive care unitPharmacologic prophylaxisTherapeutic anticoagulationCohort studyPulmonary embolismCardiopulmonary supportCare unitMechanical ventilationVenous catheterizationSevere illnessSerial sonogramsLower extremitiesEpidemiologyThrombosis
2015
Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children
Faustino EV, Li S, Silva CT, Pinto MG, Qin L, Tala JA, Rinder HM, Kupfer GM, Shapiro ED. Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 497-504. PMID: 25828784, PMCID: PMC4497863, DOI: 10.1097/pcc.0000000000000409.Peer-Reviewed Original ResearchConceptsCatheter-related thrombosisFactor VIII activityIncident thrombosisIll childrenVIII activityCentral venous catheter-related thrombosisDays of enrollmentProspective cohort studyCentral venous cathetersImportant clinical predictorsTertiary academic centerIU/dlPharmacologic thromboprophylaxisSurveillance ultrasonographyCohort studyVenous cathetersClinical predictorsThrombotic eventsOdds ratioSD increaseHigh riskThrombosisAcademic centersFactor VIIIYouden index
2014
Blood glucose as a marker of venous thromboembolism in critically ill children
Tala JA, Silva CT, Pemira S, Vidal E, Faustino EV. Blood glucose as a marker of venous thromboembolism in critically ill children. Journal Of Thrombosis And Haemostasis 2014, 12: 891-896. PMID: 24708410, PMCID: PMC4055532, DOI: 10.1111/jth.12583.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersBlood GlucoseChildChild, PreschoolChi-Square DistributionCritical IllnessFemaleHumansHyperglycemiaInfantIntensive Care Units, PediatricLogistic ModelsMaleOdds RatioPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsTime FactorsVenous ThromboembolismConceptsMaximum blood glucoseVenous thromboembolismBlood glucoseIll childrenOdds ratioPediatric intensive care unitRetrospective cohort studyCentral venous cathetersNon-diabetic childrenSeverity of illnessIntensive care unitLogistic regression modelsCohort studyVenous cathetersAntithrombotic useDiabetes mellitusPrimary outcomeCare unitHyperglycemic subjectsPrior diagnosisThromboembolismHyperglycemiaMechanical ventilatorPotential predictorsSubject characteristics
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosisEarly assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma
Silva CT, Naveed N, Bokhari S, Baker KE, Staib LH, Ibrahim SM, Muchantef K, Goodman TR. Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma. Emergency Radiology 2012, 19: 203-209. PMID: 22362422, DOI: 10.1007/s10140-012-1027-2.Peer-Reviewed Original ResearchConceptsPediatric extremity traumaExtremity traumaSite of painPediatric emergency departmentSite of injuryPain sitesEmergency departmentLimb traumaContralateral limbExtremity radiographsFracture sitePatientsFurther evaluationRadiographsTraumaSame dayEarly assessmentWhole limbIntellectual disabilityLocal hyperthermiaYoung childrenDITIEfficacyLimbFractures
2010
CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children.
Silva CT, Amaral JG, Moineddin R, Doda W, Babyn PS. CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children. American Journal Of Roentgenology 2010, 194: 772-8. PMID: 20173158, DOI: 10.2214/ajr.09.2490.Peer-Reviewed Original ResearchConceptsExtrapulmonary malignanciesCT characteristicsLung nodulesBilateral lung nodulesOncology servicesChest CTPathology resultsCommon findingRetrospective analysisMalignant lesionsBenign lesionsMalignancyBiopsyPeripheral distributionCT attenuationSolid attenuationCTChildrenNodulesLesionsDiagnosisNodule featuresSubgroupsCT imagesVariety of patternsDo additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma?
Silva CT, Doria AS, Traubici J, Moineddin R, Davila J, Shroff M. Do additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma? American Journal Of Roentgenology 2010, 194: 500-8. PMID: 20093616, DOI: 10.2214/ajr.09.2837.Peer-Reviewed Original ResearchConceptsCervical spine abnormalitiesSubluxation/dislocationLateral view radiographsPediatric patientsPediatric traumaSpine abnormalitiesDiagnostic performanceView radiographsC1-C2 rotatory subluxationRadiographic viewsCervical spine radiographyCervical spine radiographsSpinous process fracturePediatric emergency departmentSensitivity of radiographyPerformance of radiographyLateral viewFracture dislocationOdontoid fracturesProcess fracturesEmergency departmentAcute traumaRadiographic abnormalitiesRotatory subluxationSpine radiography
2009
Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience
Helm EJ, Silva CT, Roberts HC, Manson D, Seed MT, Amaral JG, Babyn PS. Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience. Pediatric Radiology 2009, 39: 685-693. PMID: 19418048, DOI: 10.1007/s00247-009-1259-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsArtificial IntelligenceChildChild, PreschoolFemaleHumansLung NeoplasmsMaleObserver VariationPattern Recognition, AutomatedPilot ProjectsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySolitary Pulmonary NoduleTomography, X-Ray ComputedConceptsPediatric oncology patientsPulmonary nodulesSensitivity of CADOncology patientsPediatric patientsPrimary tumorIRB approvalPediatric radiologistsMethodsCT scansInitial experiencePatientsLung nodulesNodule sizeNodulesAvailable CAD systemPerformance of CADRadiologistsComputer-aided detectionInitial findingsLow numberRadiologists' sensitivityObjectiveToTumorsSensitivityCardiac tamponade: appearance on CT
Silva CT, Baker K. Cardiac tamponade: appearance on CT. Pediatric Radiology 2009, 39: 523-523. PMID: 19277626, DOI: 10.1007/s00247-009-1207-8.Peer-Reviewed Original Research