Christopher Whitlow, MD, PhD, MHA, MBA
Professor and Chair, Department of Radiology & Biomedical ImagingAbout
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Titles
Professor and Chair, Department of Radiology & Biomedical Imaging
Chair, Radiology & Biomedical Imaging
Biography
Christopher Whitlow, MD, PhD, MHA, MBA, chair of radiology and biomedical imaging and assistant dean for translational research at Yale School of Medicine, focuses on advancing neuroimaging, computational data science, and translational innovation in biomedical imaging. Whitlow’s research integrates computational approaches such as artificial intelligence, deep learning, and graph theoretical network methods to analyze complex clinical and research data. His work aims to synthesize imaging, genomic, and clinical information to enhance precision diagnostics and improve patient care, particularly in oncology and neurosciences.
Whitlow’s research interests include developing and implementing advanced signal processing applications, real-time predictive analytics for oncology, and artificial intelligence-based imaging tools. He has contributed to the creation of patient-specific 3D-printed anatomical models for pre-surgical planning and patient education. Whitlow also works to establish new biomarkers for conditions such as stroke, traumatic brain injury, Alzheimer’s disease, and neurooncologic disorders, aiming to address key challenges in population health. His academic leadership extends to fostering collaborative research and supporting the growth of faculty across Yale School of Medicine and Yale New Haven Health System.
Whitlow serves as chief of radiology at Yale New Haven Hospital and radiologist-in-chief across Yale New Haven Health System. In his clinical practice, Whitlow is a neuroradiologist who evaluates and manages patients with traumatic brain injury, neurodegenerative diseases, including Alzheimer’s disease, and neurological cancers. He employs advanced imaging techniques to support diagnosis and treatment planning for a range of complex neurological conditions.
Whitlow received his medical and doctoral degrees from Wake Forest University School of Medicine and earned a master’s degree in health care administration from the University of North Carolina at Chapel Hill. He completed his internship at Moses Cone Memorial Hospital and his residency and fellowship at Wake Forest University School of Medicine. He has held leadership roles in national professional societies, including serving as president of the American Society of Functional Neuroradiology and contributing to committees of the Radiological Society of North America, American College of Radiology, and American Society of Neuroradiology.
Appointments
Radiology & Biomedical Imaging
ChairDualRadiology & Biomedical Imaging
ProfessorPrimary
Other Departments & Organizations
- Clinical Radiology
- Neuroradiology
- Radiology & Biomedical Imaging
- Radiology Informatics and Image Processing Laboratory
- Yale Biomedical Imaging Institute
- Yale Medicine
- Yale New Haven Health System
Education & Training
- MBA
- Wake Forest University (2026)
- MHA
- University of North Carolina at Chapel Hill (2014)
- Fellow
- Wake Forest University School of Medicine (2011)
- Resident
- Wake Forest University School of Medicine (2009)
- Intern
- Moses Cone Memorial Hospital (2005)
- MD
- Wake Forest University School of Medicine (2004)
- PhD
- Wake Forest University School of Medicine (2004)
Research
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Research at a Glance
Yale Co-Authors
Publications Timeline
Qing Lyu
Ajay Malhotra, MBBS, MD, MMM, FACR
Christopher Gange, MD
Gordon Sze, MD
Jason Johnson, MD, MBA, DABR
Publications
2026
A multimodal MRI–radiomics deep learning model for survival risk stratification after gamma knife radiosurgery in patients with brain metastases: A multicenter retrospective study
Chen Y, Yuan Q, Cramer C, Helis C, He G, Chen C, Choi A, Young P, Wang Y, Xing F, Ruiz J, Tan J, Lyu Q, Whitlow C, Munley M, Willey J, Tian J, Chan M, Jiang Y. A multimodal MRI–radiomics deep learning model for survival risk stratification after gamma knife radiosurgery in patients with brain metastases: A multicenter retrospective study. Radiotherapy And Oncology 2026, 222: 111686. PMID: 42419433, DOI: 10.1016/j.radonc.2026.111686.Peer-Reviewed Original ResearchAltmetricDietary Pattern-Induced Gut Microbiota Differences Are Associated with White Matter Volume Changes in Middle-Aged Female Macaques
Frye B, Cooper H, Negrey J, Sutphen C, Nagpal R, Kim J, Barcus R, Lockhart S, Whitlow C, Tooze J, Yadav H, Craft S, Register T, Shively C. Dietary Pattern-Induced Gut Microbiota Differences Are Associated with White Matter Volume Changes in Middle-Aged Female Macaques. Nutrients 2026, 18: 1124. PMID: 41978176, PMCID: PMC13075110, DOI: 10.3390/nu18071124.Peer-Reviewed Original ResearchAltmetricSynthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent
Bhoopal B, Gollapelli K, Damuka N, Krizan I, Miller M, Fitzgerald R, Amesar N, Mumbaraddi D, Zhu D, Cervera-Juanes R, Jadiya P, Whitlow C, Sai K. Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent. Journal Of Medicinal Chemistry 2026, 69: 7933-7944. PMID: 41851960, PMCID: PMC13402958, DOI: 10.1021/acs.jmedchem.5c03351.Peer-Reviewed Original ResearchCitationsAltmetricCurrent State of Artificial Intelligence Adoption and Implementation in Neuroradiology Departments: Insights from a US National Survey.
Wintermark M, Allen J, Bhala R, Derdeyn C, Hess C, Hoxworth J, Huisman T, Jayaraman M, Malhotra A, McKinney A, Mossa-Basha M, Policeni B, Poussaint T, Saindane A, Vagal A, Whitlow C. Current State of Artificial Intelligence Adoption and Implementation in Neuroradiology Departments: Insights from a US National Survey. American Journal Of Neuroradiology 2026, 47: 2245-2248. PMID: 41791836, PMCID: PMC13537401, DOI: 10.3174/ajnr.a9279.Peer-Reviewed Original ResearchCitationsAltmetricImpact of Imaging Acquisition and Protocol Variability on Artificial Intelligence Model Performance: A Secondary Analysis of the ASFNR Artificial Intelligence Competition.
Zhu G, Ozkara B, Allen J, Barboriak D, Chaudhari R, Chen H, Chukus A, Etter M, Filippi C, Flanders A, Godwin R, Hashmi S, Hess C, Hsu K, Jiang B, Lui Y, Maldjian J, Michel P, Nalawade S, Raghavan P, Sair H, Welker K, Whitlow C, Zaharchuk G, Wintermark M. Impact of Imaging Acquisition and Protocol Variability on Artificial Intelligence Model Performance: A Secondary Analysis of the ASFNR Artificial Intelligence Competition. American Journal Of Neuroradiology 2026, 47: 2366-2371. PMID: 41760384, PMCID: PMC13537418, DOI: 10.3174/ajnr.a9266.Peer-Reviewed Original ResearchCitationsUnderstanding the Neural Connectivity Changes of Repetitive Head Impacts in Youth Football Players: A Cross-Sectional MEG Analysis
Bell N, Xi Y, da Fonseca N, Urban J, Powers A, Wagner B, Whitlow C, Proskovec A, Stitzel J, Yu F, Maldjian J, Davenport E. Understanding the Neural Connectivity Changes of Repetitive Head Impacts in Youth Football Players: A Cross-Sectional MEG Analysis. Brain Connectivity 2026, 16: 118-127. PMID: 41709584, DOI: 10.1177/21580014261425220.Peer-Reviewed Original ResearchAltmetricTotal-body Irradiation Reduces Cerebrovascular Reactivity in Rhesus Macaques (Macaca mulatta)
Johnson B, Lipford M, Barcus R, Schaaf G, Andrews R, Kim J, Olson J, Deycmar S, Reed C, Whitlow C, Cline J. Total-body Irradiation Reduces Cerebrovascular Reactivity in Rhesus Macaques (Macaca mulatta). International Journal Of Radiation Oncology • Biology • Physics 2026, 125: 1190-1201. PMID: 41690557, PMCID: PMC13088117, DOI: 10.1016/j.ijrobp.2026.01.043.Peer-Reviewed Original ResearchPlasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA
Lockhart S, Sutphen C, Tanley J, Gonzalez‐Ortiz F, Kac P, Habes M, Heckbert S, Ashton N, Mielke M, Koeppe R, Rudolph M, Sai K, Whitlow C, Hiatt K, Craft S, Register T, Hayden K, Rapp S, Sachs B, Zetterberg H, Blennow K, Karikari T, Hughes T. Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA. Alzheimer's & Dementia 2026, 22: e71131. PMID: 41630612, PMCID: PMC12865319, DOI: 10.1002/alz.71131.Peer-Reviewed Original ResearchCitationsAltmetricPET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys
Bhoopal B, Frye B, Miller M, Bansode A, Gollapelli K, Barcus R, Lockhart S, Damuka N, Sutphen C, Fitzgerald R, Kim J, Baxter M, Jorgensen M, Craft S, Register T, Whitlow C, Shively C, Solingapuram Sai K. PET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys. Journal Of Translational Medicine 2026, 24: 42. PMID: 41501910, PMCID: PMC12784507, DOI: 10.1186/s12967-025-07642-5.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players
Yu K, Wiesman A, Davenport E, Flashman L, Urban J, Nagarajan S, Sai K, Stitzel J, Maldjian J, Whitlow C. Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players. IScience 2025, 29: 114575. PMID: 41623461, PMCID: PMC12856156, DOI: 10.1016/j.isci.2025.114575.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity Society for Neuroscience
1998 - PresentProfessional OrganizationsMemberactivity Alpha Omega Alpha (AOA) Honor Medical Society
2004 - PresentProfessional OrganizationsMemberactivity International Society of Cerebral Blood Flow and Metabolism
2004 - PresentProfessional OrganizationsMemberactivity Radiological Society of North America (RSNA)
2004 - PresentProfessional OrganizationsMemberactivity American Society of Neuroradiology (ASNR)
2005 - PresentProfessional OrganizationsMember
News
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News
- June 17, 2026
Diagnostic Radiology Graduates 16 Residents
- March 24, 2026
AI in Cancer Workshop: Advancing Precision Medicine through Interdisciplinary Innovation
- December 01, 2025
Christopher Whitlow on the Research and Practice—and Creativity—of Radiology
- July 31, 2025
Christopher Whitlow, MD, PhD, MHA, to be Appointed Chair, Department of Radiology and Biomedical Imaging