2020
Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light
Hendrickson JE, Mendoza H, Ross R, Siddon AJ, Gowda L, Hauser RG, Schulz WL, Tormey CA. Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light. Transfusion 2020, 60: 650-651. PMID: 32128834, DOI: 10.1111/trf.15691.Peer-Reviewed Original Research
2018
Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model.
Madrid DJ, Santhanakrishnan M, Liu J, Gibb DR, Liu D, Natarajan P, Beitler D, Shi Z, Mo C, Tormey CA, Patel SR, Stowell SR, Hendrickson JE. Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model. Blood Transfusion 2018, 17: 368-377. PMID: 30418129, PMCID: PMC6774925, DOI: 10.2450/2018.0178-18.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionBlood cell transfusionTransfusion of plateletsAlloimmune responseRed blood cellsCell transfusionWild-type recipientsBlood cellsImmune responseMurine modelRed blood cell alloimmunisationCD40/CD40L interactionHuman KEL glycoproteinWild-type C57BL/6Humoral immune responseAdaptive immune responsesDevelopment of alloantibodiesPlatelet-rich plasmaEndogenous plateletsCD40L interactionRecipient treatmentTransfusionDanger signalsCD40LTransgenic donorsVisualization of bacterial contamination in an apheresis platelet unit
Siddon AJ, Snyder EL, Tormey CA. Visualization of bacterial contamination in an apheresis platelet unit. Journal Of Clinical Apheresis 2018, 33: 671-672. PMID: 30242893, DOI: 10.1002/jca.21649.Peer-Reviewed Original ResearchVery low rate of anti‐D development in male, primarily immunocompetent patients transfused with D‐mismatched platelets
Curtis G, Scott M, Orengo L, Hendrickson JE, Tormey CA. Very low rate of anti‐D development in male, primarily immunocompetent patients transfused with D‐mismatched platelets. Transfusion 2018, 58: 1568-1569. PMID: 29949189, DOI: 10.1111/trf.14614.Peer-Reviewed Original ResearchMeSH KeywordsBlood Component RemovalBlood PlateletsHumansMalePlatelet TransfusionProspective StudiesRho(D) Immune Globulin
2016
Modelling gas exchange during platelet storage without agitation
Torres R, Tormey CA. Modelling gas exchange during platelet storage without agitation. Vox Sanguinis 2016, 111: 445-448. PMID: 27864979, DOI: 10.1111/vox.12452.Peer-Reviewed Original ResearchFluid motion and shear forces in platelet storage bags with different modes of agitation
Torres R, Tormey CA, Stack G. Fluid motion and shear forces in platelet storage bags with different modes of agitation. Vox Sanguinis 2016, 111: 209-212. PMID: 27078040, PMCID: PMC4981547, DOI: 10.1111/vox.12409.Peer-Reviewed Original ResearchCD8+ T cells mediate antibody-independent platelet clearance in mice
Arthur CM, Patel SR, Sullivan HC, Winkler AM, Tormey CA, Hendrickson JE, Stowell SR. CD8+ T cells mediate antibody-independent platelet clearance in mice. Blood 2016, 127: 1823-1827. PMID: 26787734, PMCID: PMC4825415, DOI: 10.1182/blood-2015-10-673426.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PlateletsCD8-Positive T-LymphocytesHumansIsoantibodiesMicePlatelet TransfusionConceptsPlatelet clearancePlatelet removalImportant therapeutic interventionPlatelet transfusionsNonimmune mechanismsT cellsTherapeutic outcomesAlloantibodiesTherapeutic interventionsAppropriate managementTransfusionClearanceSole mediatorPatientsVariety of mechanismsComplete absenceNumerous studiesCD8Clear mechanismCellsAbsenceMiceIndividualsPrevention
2014
Use of a Cytokine-Release Assay to Demonstrate Loss of Platelet Secretory Capacity During Blood Bank Processing and Storage
Tormey CA, Stack G. Use of a Cytokine-Release Assay to Demonstrate Loss of Platelet Secretory Capacity During Blood Bank Processing and Storage. Archives Of Pathology & Laboratory Medicine 2014, 138: 1481-7. PMID: 25357109, DOI: 10.5858/arpa.2013-0680-oa.Peer-Reviewed Original Research
2013
Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components
Xiao W, Tormey CA, Capetillo A, Maitta RW. Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components. Vox Sanguinis 2013, 105: 334-340. PMID: 23802769, DOI: 10.1111/vox.12063.Peer-Reviewed Original ResearchConceptsAllergic transfusion reactionsTransfusion reactionsATR rateApheresis plateletsPlatelet componentsApheresis componentsAcademic medical centerABO mismatchAdverse eventsAntigen exposurePlatelet transfusionsPlatelet countDonor factorsMedical CenterApheresis productsApheresis unitsPlatelet productsStudy periodTransfusionPlateletsSimilar ratesFurther investigation