2021
Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent plasmaSevere COVID-19Convalescent plasmaPlasma recipientsHospital mortalityUnexposed cohortCCP administrationSevere COVID-19 infectionPropensity score-matched analysisCOVID-19Limited therapeutic optionsCOVID-19 infectionCoronavirus disease 2019CCP recipientsHospital stayPrimary endpointSecondary endpointsHospital daysHospital dischargeEarly administrationComplete followMechanical ventilationTherapeutic optionsClinical differencesSevere disease
2020
Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation
Zerra PE, Arthur CM, Chonat S, Maier CL, Mener A, Shin S, Allen JWL, Baldwin WH, Cox C, Verkerke H, Jajosky RP, Tormey CA, Meeks SL, Stowell SR. Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation. Frontiers In Immunology 2020, 11: 905. PMID: 32582142, PMCID: PMC7295897, DOI: 10.3389/fimmu.2020.00905.Peer-Reviewed Original ResearchConceptsAnti-FVIII antibody formationAnti-FVIII antibodiesKnockout recipientsAntibody formationWT recipientsFc gamma receptorsAnti-FVIII antibody developmentGamma receptorsRole of FcγRsFVIII exposureAntibody levelsWT miceTherapeutic optionsAntibody responseC3 knockoutTarget antigenHemophilia AImmune systemFcγRAntibody developmentInfusionRecipientsAntibodiesPotential mechanismsPatients
2009
Platelet-Related Bleeding: An Update on Diagnostic Modalities and Therapeutic Options
Peddinghaus ME, Tormey CA. Platelet-Related Bleeding: An Update on Diagnostic Modalities and Therapeutic Options. Clinics In Laboratory Medicine 2009, 29: 175-191. PMID: 19665674, DOI: 10.1016/j.cll.2009.03.004.Peer-Reviewed Original ResearchConceptsPlatelet function testingFunction testingCare platelet function testingChronic clinical settingsPlatelet-related bleedingLife-threatening problemTransfusion strategyPlatelet dysfunctionTherapeutic optionsComponent therapyDiagnostic modalitiesClinical settingBleedingPatientsInitial studyLaboratory assaysTransfusionDysfunctionTherapyCare