2017
A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia
Zheng Y, Pollak J, Henderson K, Hendrickson JE, Tormey CA. A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia. Transfusion 2017, 58: 775-780. PMID: 29210083, DOI: 10.1111/trf.14451.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaRBC alloimmunization rateAlloimmunization rateHHT patientsRBC transfusionHemorrhagic telangiectasiaRed blood cell transfusionProphylactic antigen matchingBlood cell transfusionTertiary care facilityMultiple arteriovenous malformationsAutosomal dominant disorderCommon alloantibodiesHHT populationCell transfusionSurgical bleedingTransfusion burdenAntigen matchingSpontaneous hemorrhageRetrospective studyMedical recordsArteriovenous malformationsCare facilitiesPatientsDisease pathophysiology
2016
Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery
Siddon AJ, Tormey CA. Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery. Lab Medicine 2016, 47: e35-e37. PMID: 27378481, PMCID: PMC4985779, DOI: 10.1093/labmed/lmw037.Peer-Reviewed Original ResearchConceptsCongenital factor X deficiencyFactor X deficiencyX deficiencyExcessive bleedingComplex concentrateFour-factor prothrombin complex concentrateFactor prothrombin complex concentrateFirst-line therapyAnterior cervical discectomySetting of traumaProthrombin complex concentrateFresh frozen plasmaRare coagulation disorderMajor neurosurgeryCervical discectomyThromboembolic complicationsSpontaneous hemorrhageCoagulation disordersFrozen plasmaInvasive proceduresOperative casesBleedingWhite menDeficiencyDisorders