2016
Understanding red blood cell alloimmunization triggers
Hendrickson JE, Tormey CA. Understanding red blood cell alloimmunization triggers. Hematology 2016, 2016: 446-451. PMID: 27913514, PMCID: PMC6142457, DOI: 10.1182/asheducation-2016.1.446.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRed blood cellsRisk factorsBlood cellsWhite blood cellsBlood group antigensPregnancy outcomesAlloantibody formationRBC alloantibodiesRBC transfusionRecipient factorsTransfusion safetyAlloimmunizationAnimal modelsHuman studiesPrevention strategiesDonor plasmaDanger signalsParticular antigenGroup antigensAntigenTransfusionPregnancyNonrespondersCellsAntigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice
Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood 2016, 128: 3159-3168. PMID: 27688803, PMCID: PMC5201095, DOI: 10.1182/blood-2016-06-724732.Peer-Reviewed Original ResearchConceptsMechanism of actionKO miceRed blood cell alloimmunizationGlycoprotein antigenMurine RBCsHuman KEL glycoproteinRh immune globulinSingle knockout miceWild-type recipientsImmunoprophylaxis programKO recipientsPrevent alloimmunizationImmune globulinSerious complicationsAntigen modulationMurine modelImmunoprophylaxisFcγ receptorsKEL antigenAlloimmunizationFlow cytometryRapid clearanceWestern blotMiceAntigenEstimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures
Stack G, Tormey CA. Estimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures. British Journal Of Haematology 2016, 175: 154-160. PMID: 27340943, DOI: 10.1111/bjh.14175.Peer-Reviewed Original ResearchConceptsAntigen immunogenicityPre-existing antibodiesLow-frequency antigensMean RBCHigh-frequency antigensHospital transfusion servicesTransfusion exposureAntibody frequencyAntigen exposureRBC exposureTransfusion servicesImmunogenicityRBC unitsAntigenPatientsBlood groupReference antigenUnit exposureExposureFold increaseSmall increase
2015
Routine non‐ABO blood group antigen genotyping in sickle cell disease: the new frontier in pretransfusion testing?
Tormey CA, Hendrickson JE. Routine non‐ABO blood group antigen genotyping in sickle cell disease: the new frontier in pretransfusion testing? Transfusion 2015, 55: 1374-1377. PMID: 26094720, DOI: 10.1111/trf.13065.Peer-Reviewed Original Research
2009
Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies
Tormey CA, Stack G. Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies. Blood 2009, 114: 4279-4282. PMID: 19713462, DOI: 10.1182/blood-2009-06-227793.Peer-Reviewed Original Research